解放军医学院学报2017，Vol.38Issue(5)：409-413,5.DOI:10.3969/j.issn.2095-5227.2017.05.006
替罗非班治疗进展性缺血性卒中的疗效和安全性观察
A preliminary study on effectiveness and safety of Tirofiban for progressive ischemic stroke
摘要
Abstract
Objective To explore the effectiveness and safety of tirofiban for progressive ischemic stroke (PIS). Methods We collected six PIS patients treated with tirofiban who admitted to our hospital between January 2016 and December 2016. Demographic data, ischemic stroke risk factors, location of new infarction and etiologic mechanisms, time to tirofiban administration, duration and dosage. The National Institute of Health Stroke Scale (NIHSS) scores at different time points and complications were summarized. Results Six patients were included, and progressive ischemic stroke lesions located in anterior circulation in 3 cases and in posterior circulation in 3 cases, respectively. Underlying mechanisms ofprogression included large artery or penetrating artery initial segment atherothrombosis, artery-to-artery embolism, and hemodynamic impairment/ impaired emboli clearance. The duration of tirofiban infusion was 34–184 (75±54.4) h with the dosage of 0.1-0.25 (0.19±0.06) mg/h. NIHSS score reduced by 3.0±2.1 points at 7 days after tirofiban infusion. No hemorrhagic complications were observed. Conclusion Tirofiban may be able to prevent early worsening of ischemic stroke without increasing the risk of bleeding. Further studies of tirofiban for PIS are needed.关键词
进展性卒中/替罗非班/脑梗死Key words
progressive stroke/tirofiban/cerebral infarction分类
医药卫生引用本文复制引用
郝静,赵娜,孔孟丹,苏慧,曹向宇,刘新峰,杜志华,焦格,田成林..替罗非班治疗进展性缺血性卒中的疗效和安全性观察[J].解放军医学院学报,2017,38(5):409-413,5.基金项目
海南省医药卫生科研项目(1423320 （）
54A1006) Supported by for Medical Scientific Research Projects of Hainan Province (1423320 （）
54A1006) （）
