解放军医学院学报2017，Vol.38Issue(5)：420-422,3.DOI:10.3969/j.issn.2095-5227.2017.05.009
窄谱中波紫外线治疗寻常型银屑病的优化方案探究
Optimizing therapeutics irradiation scheme on poriasis vulgaris through narrow-spectrum UVB
摘要
Abstract
Objective To explore the optimal irradiation scheme of narrow band ultraviolet irradiation by analyzing the different frequency and dose increment in the treatment of psoriasis vulgaris. Methods A total of 128 patients with soriasis vulgaris recruited from March 2015 to June 2016 in Chinese PLA General Hospital were randomly divided into group A (0.04 J/cm2 dose increment, irradiation once a day), group B (0.07 J/cm2 dose increment, irradiation once a day) and control group (group C, 0.1 J/cm2 dose increment, irradiation 3 times a week). All patients were treated by whole body NB-UVB radiation combined with kalbrometilointment and halomethasone ointment. Age, disease course and severity index (PASI) score before treatment between the three groups showed no significant difference. The efficacy was evaluated according to the drop in proportion of psoriasis area and PASI at the 10th day and 20th day to calculate the improvement rate. The adverse reactions during irradiation were recorded.Results After 10 days treatment, the improvement rate of group B(47.81%±11.87%) was higher than that of group A (33.57%±7.30%) with statistically significant difference (P < 0.05), and both group A and group B had advantage over the group C (P < 0.05); After 20 days treatment, the improvement rate of group B(56.2%±19.8%) was still higher than that of group A (43.3%±19.5%) with significant difference (P < 0.05), while no statistically significant difference in the improvement rate was found between group A and group C (P =0.475). Conclusion The radiation protocol (0.07 J/cm2 dose increment, once a day) is recommended as the first choice in the treatment of psoriasis vulgaris with narrow-band UVB due to its rapid onset, short durationand mild side effects.关键词
银屑病/窄谱中波紫外线/照射参数Key words
psoriasis/narrowband ultraviolet B/irradiation parameters分类
医药卫生引用本文复制引用
丁香玉,刘丹,刘冰,杨怡,李承新..窄谱中波紫外线治疗寻常型银屑病的优化方案探究[J].解放军医学院学报,2017,38(5):420-422,3.基金项目
国家自然科学基金项目(81572680) Supported by the National Natrual Scinence Foundation of China(81572680) （81572680）
