解放军医学院学报2017，Vol.38Issue(5)：440-444,5.DOI:10.3969/j.issn.2095-5227.2017.05.015
粒状头样2和表皮生长因子受体蛋白在食管鳞癌中的表达及预后判断价值
Expressions of grainyhead-like 2 and epidermal growth factor receptor in esophageal squamous cell carcinoma and their prognostic significance
林吉兴 1王柏霖 1刘阳 2梁朝阳 1郭俊唐 1杨博 2王钰琦2
作者信息
- 1. 解放军总医院海南分院,海南三亚 572000
- 2. 解放军总医院,北京 100853
- 折叠
摘要
Abstract
Objective To investigate the expressions of grainyhead-like2 (GRHL2) and epidermal growth factor receptor (EGFR) in esophageal squamous cell carcinoma (ESCC) and their prognostic significance. Methods EnVision immunohistochemical method was used to detect the expressions of GRHL2 and EGFR in ESCC and adjacent normal squamous epithelium in 63 patients who received radical resection of esophageal cancer in Chinese PLA General Hospital and Hainan Branch Hospital. Results GRHL2 and EGFR expressed significantly higher in ESCC than in adjacent normal tissues (P < 0.05, respectively). The expression of GRHL2 was significantly correlated with tumor size, differentiation, lymph node metastasis and tumor staging (P < 0.05, respectively). The expression of EGFR was correlated with differentiation degree and tumor staging (P < 0.05, respectively). Spearman correlation analysis showed a negative correlation between GRHL2 and EGFR (r =-0.359, P =0.004). Kaplan-Meier survival curve analysis showed that disease free survival (DFS) and overall survival (OS) in patients with GRHL2 low expression were shorter than those with GRHL2 high expression (DFS: 18.447±1.101 vs 38.976±1.7 months; OS: 32.902±1.017 vs 54.015±2.208 months; P = 0.000, respectively). On the contrary, DFS and OS in patients with EGFR high expression were shorter than those with EGFR low expression (DFS: 22.190±1.564 vs 31.810±2.487 months; OS: 36.522±1.931 vs. 48.168±3.331 months; P < 0.05, respectively).COX regression analysis showed that GRHL2, lymph node metastasis and tumor staging were independent prognostic factors for postoperative ESCC. Conclusion The abnormal expression of GRHL2 and EGFR may be involved in the occurrence anddevelopment of ESCC. Combined detection of GRHL2 and EGFR may help to determine the prognosis of patients with ESCC.关键词
食管肿瘤/粒状头样2/表皮生长因子受体/免疫组织化学Key words
esophageal neoplasm/grainyhead-like2/epidermal growth factor receptor/immunohistochemistry分类
医药卫生引用本文复制引用
林吉兴,王柏霖,刘阳,梁朝阳,郭俊唐,杨博,王钰琦..粒状头样2和表皮生长因子受体蛋白在食管鳞癌中的表达及预后判断价值[J].解放军医学院学报,2017,38(5):440-444,5.
