解放军医学院学报2017，Vol.38Issue(5)：445-448,4.DOI:10.3969/j.issn.2095-5227.2017.05.016
供受者体表面积匹配程度对活体供肾肾移植效果的影响
Detrimental effect of donor and recipient body surface incompatibility on graft outcomes in living-donor kidney transplantation
王振 1钱叶勇 1柏宏伟 1范宇 1于涛 1刘路鹏 1李钢 1石炳毅1
作者信息
- 1. 解放军第309医院全军器官移植研究所泌尿二科,北京 100091
- 折叠
摘要
Abstract
Objective To evaluate the influence of the donor recipient body surface mismatch on renal graft outcome in living donor kidney transplantation(LDKT). Methods In this prospective study, 286 living kidney transplantation donor–recipient pairs were included. All pairs were stratified into two categories by a break-up of donor/recipient body surface area ratio (D/R BSA-ratio) < 0.9 or ≥ 0.9. The impact of D/B BSA-ratio on recipient allograft outcome was assessed. Results Donors in both groups had similar glomerular filtration rate (GFR). The estimated GFR of recipients in D/R BSA-ratio < 0.9 group were significantly lower than those in D/R BSA-ratio ≥ 0.9 group at 1, 3, 6, 12 months post-transplantation (P < 0.001, respectively). The lower D/B BSA-ratio ( < 0.9) conferred greater risk for proteinuria(P < 0.01, respectively). Furthermore, the Kaplan–Meier estimates showed a significantassociation between donor/recipient BSA ratio and risk of allograft function impairment (P < 0.001). The D/R BSA-ratio < 0.9 was independently associated with allograft function impairment in COX regression model (OR: 1.25, 95% CI : 1.11–1.46; P < 0.01).Conclusion In conclusion, the lower D/R BSA-ratio is associated with graft function impairment after kidney transplantation. Thefindings suggest that avoiding donor and recipient BSA incompatibility confers an outcome advantage in LDKT.关键词
肾移植/活体供肾/体表面积Key words
renal transplantation/living donor/body surface area分类
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王振,钱叶勇,柏宏伟,范宇,于涛,刘路鹏,李钢,石炳毅..供受者体表面积匹配程度对活体供肾肾移植效果的影响[J].解放军医学院学报,2017,38(5):445-448,4.
