临床肝胆病杂志2017，Vol.33Issue(5)：864-868,5.DOI:10.3969/j.issn.1001-5256.2017.05.014
TGFβ1对原发性肝癌诊断价值的Meta分析
Value of transforming growth factor-β1 in diagnosis of primary liver cancer: a meta-analysis
摘要
Abstract
Objective To investigate the value of transforming growth factor-β1 (TGFβ1) in the diagnosis of primary liver cancer using a meta-analysis.Methods PubMed,EMBASE,Cochrane Library,CBM,CNKI,Wanfang Data,and VIP were searched for articles on TGFβ1 in the diagnosis of primary liver cancer published up to June 30,2016.The Overview Quality Assessment Questionnaire was used to evaluate the quality of articles screened out.Stata 13.0 software was used for the analysis of diagnostic odds ratio,positive likelihood ratio,and negative likelihood ratio,the summary receiver operating characteristic (SROC) curve was plotted,and publication bias was tested.The confidence level was expressed as 95％ confidence interval (95％ CI).The Q test and I2 test were used for testing heterogeneity,and a subgroup analysis was also performed.Results A total of 16 articles were included,with 1124 patients in liver cancer group and 1443 patients in control group.The sensitivity was 0.68 (95 ％ CI:0.52-0.80) and the specificity was 0.85 (95 ％ CI:0.74-0.92).The diagnostic odds ratio,positive likelihood ratio,and negative likelihood ratio were 11.75 (95 ％ CI:6.18-22.36),4.6 (95％ CI:2.7-7.9),and 0.38 (95％CI:0.26-0.56),respectively.The area under the SROC curve was 0.84 (95％ CI:0.80-0.87).The subgroup analysis showed that compared with immunohistochemistry,ELISA had higher positive likelihood ratio and diagnostic odds ratio and a larger area under the SROC curve,as well as a lower negative likelihood ratio.There was heterogeneity among the articles included,and the main sources of heterogeneity were different underlying liver diseases in patients,different types of diseases in non-primary liver cancer group (including benign control group and normal control group),and difference in experimental design.The Deeks funnel plot showed no significant publication bias.Conclusion TGFβ1 has high sensitivity and specificity in the diagnosis of liver cancer and may become an auxiliary index for the diagnosis of liver cancer.关键词
肝肿瘤/转化生长因子β1/诊断/Meta分析Key words
liver neoplasms/transforming growth factor beta1/diagnosis/meta-analysis分类
医药卫生引用本文复制引用
莫晓丽,刘洁,诸佳瑜,陈闯,欧杰,毛素菲..TGFβ1对原发性肝癌诊断价值的Meta分析[J].临床肝胆病杂志,2017,33(5):864-868,5.基金项目
广西科学研究与技术开发计划项目(桂科攻1598012-54) （桂科攻1598012-54）
广西自然科学基金面上项目(2014GXNSFAA118191) （2014GXNSFAA118191）
