内科理论与实践2016，Vol.11Issue(6)：366-370,5.DOI:10.16138/j.1673-6087.2016.06.008
白塞病375例临床特点及其不同性别的临床异质性研究
Behcet's disease in 375 patients: clinical characteristics and gender differences
摘要
Abstract
Objective To analyze the clinical characteristics of Behcet's disease (BD) and the gender differences in a cohort of patients.Methods A total of 375 BD patients at Huadong Hospital from October 2013 to October 2015 were enrolled,and the clinical manifestations,system involvement and gender differences were analyzed.Results The average age of BD onset was (38±13) years,and the average duration of disease was (7.69±7.39) years.The most common clinical manifestation was oral ulcer,followed by genital ulcer (64.5％),erythema nodosum (41.6％) and ocular involvement (38.7％).Oral ulcer was the most common first symptom (85.3％),followed by erythema nodosum (5.3％),ophthalmia (3.2％),genital ulcer (2.1％),gastrointestinal ulcer (1.9％),joint inflammatory/joint pain (1.9％) and fever (0.3％).Gender differences in clinical manifestations revealed that more ophthalmitis and acne-like rash were seen in male (P＜0.001,P=0.001),and higher genital ulcer incidence and more blood system involvement were found in female patients (P=0.040,P=0.024).Generally ocular damage and gastrointestinal damage didn't coexist.Laboratory tests showed that erythrocyte sedimentation rate(ESR),IgG and IgM in female patients were significantly higher than those in males (P=0.001,0.012,0.009,respectively).Conclusions The clinical manifestation of BD varies,and multiple systems may be involved.There are gender differences in BD clinical manifestation.关键词
白塞病/性别/临床特点Key words
Behcet's disease/Gender difference/Clinical manifestation分类
医药卫生引用本文复制引用
申艳,罗丹,鲍华芳,蔡剑飞,邹峻,管剑龙..白塞病375例临床特点及其不同性别的临床异质性研究[J].内科理论与实践,2016,11(6):366-370,5.基金项目
上海市卫生系统重要疾病联合攻关项目(项目编号:2014ZYJB0010) （项目编号:2014ZYJB0010）
