内科理论与实践2016，Vol.11Issue(6)：391-396,6.DOI:10.16138/j.1673-6087.2016.06.013
微小残留病灶与慢性淋巴细胞白血病预后的相关性研究
Prognostic impact of minimal residual disease for patients with chronic lymphocytic leukemia
摘要
Abstract
Objective To evaluate the prognostic impact of minimal residual disease (MRD) in different therapeutic regimens for patients with chronic lymphocytic leukemia (CLL).Methods One hundred and thirty four CLL patients from January 2006 to April 2016 were enrolled in this retrospective study.The efficacy of different therapeutic regimens and prognostic value of MRD were analyzed.Results The 7 years overall survival (OS) and progression-free survival (PFS) in the MRD negative group were 85.0％ and 55.6％ after three cycles,compared with 65.7％ and 37.2％ in MRD positive group (P=0.065,0.049,respectively).The MRD negative group associated with longer PFS,which was statistically significant.Patients were divided into three subgroups:MRD negativity occurred within three cycles,MRD negativity occurred within six cycles and MRD positivity remained consistent after six cycles.The 7 years PFS were 55.6％,42.8％ and 31.5％,respectively(P=0.046).Conclusions Patients with negative MRD showed advantages in PFS.This study suggested that the sooner the MRD turns negative,the better is the long term survival.关键词
慢性淋巴细胞白血病/微小残留病灶/预后因素Key words
Chronic lymphocytic leukemia/Minimal residual disease/Prognostic impact分类
医药卫生引用本文复制引用
张佼佼,糜坚青..微小残留病灶与慢性淋巴细胞白血病预后的相关性研究[J].内科理论与实践,2016,11(6):391-396,6.基金项目
上海市国际科技合作基金项目(项目编号:15410710200) （项目编号:15410710200）
