药学研究2017，Vol.36Issue(5)：249-254,258,7.DOI:10.13506/j.cnki.jpr.2017.05.001
非雄激素竞争型雄激素受体拮抗剂设计策略
Design strategy of anti-androgen targeting the non-HBP sites of androgen receptor
摘要
Abstract
Androgen receptor (AR) is the most important target for the therapy of prostate cancer.However,the drug resistance during the treatment becomes the greatest challenge.Herein,we gave an overview of the structure and functions of AR and the drug resistances due to the mutations in the HBP site.Then this article summarized the design strategy of the AR antagonists targeting the non-HBP sites of AR,which should help to the development of novel anti-prostate cancer drugs.关键词
雄激素受体/抗前列腺癌/雄激素受体拮抗剂/激活功能区2/结合功能区3/去势低抗性前列腺癌Key words
Androgen receptor/Anti-prostate cancer/Anti-androgen/AF2/BF3/CRPC分类
医药卫生引用本文复制引用
刘阳光,吴萌,岑山,周金明..非雄激素竞争型雄激素受体拮抗剂设计策略[J].药学研究,2017,36(5):249-254,258,7.基金项目
国家自然科学基金(No.81672559、No.81001402、No.81311120299) （No.81672559、No.81001402、No.81311120299）
