药学研究2017，Vol.36Issue(5)：272-275,4.DOI:10.13506/j.cnki.jpr.2017.05.007
驱动器的规格与吸入辅助装置对气雾剂体外沉积性质的影响
Effect of actuator dimensions and add-on devices for inhalation on the deposition of metered dose inhaler in vitro
摘要
Abstract
Objective To investigate effects of actuator dimensions(the aperture and the hole length)and add-on devices for inhalation on the deposition of metered dose inhaler in vitro.Methods Self-made metered dose inhalers(MDI) of fluticasone propionate were selected as the model drug,and then assembled different dimensions of actuators.The deposition of metered dose inhaler in vitro was determined by Andersen cascade impactor(ACI).Fluticasone propionate aerosols were loaded on specific actuator.Thus,a comparative study was conducted in vitro deposition with and without add-on devices.Results When the value of aperture was fixed,increasing the hole length could reduce the amount of residue in the actuator and increase the drug deposited in the L type connection tube.Moreover,the deposition of fine particle distribution decreased slightly.Likewise,when the value of the hole length was fixed,increasing the diameter could reduce the amount of residue in the actuator and increase the amount of drug deposited in the L type connection tube.At the same time,the value of fine particle distribution was decreased.According to the experiment results,the characteristic of suspension aerosol and the actual use,actuator of 0.42 mm aperture and 0.70 mm hole length can be chosen as the priority.Add-on device can hold back the big particle,thus the drug deposition in the L type connection tube was greatly reduced,and the value of fine particle distribution is increased.Conclusion Actuator dimensions can affect the deposition of metered dose inhaler in vitro.According to the specific characteristics of aerosol products(solution or suspension,raw material particle size),actuators can be chosen in the drug research.The use of add-on devices can improve the drug utilization of aerosol,and it was recommend that patients use the add-on devices for inhalation.关键词
吸入气雾剂/驱动器/Andersen多级撞击器/吸入辅助装置Key words
Metered dose inhaler/Actuator/Andersen cascade impactor/Add-on devices for inhalation分类
化学化工引用本文复制引用
陈保垒,朱俊,卢嘉彤,金坚..驱动器的规格与吸入辅助装置对气雾剂体外沉积性质的影响[J].药学研究,2017,36(5):272-275,4.基金项目
国家自然科学基金面上项目(No.81273437) （No.81273437）
