山东医药2017，Vol.57Issue(17)：7-9,3.DOI:10.3969/j.issn.1002-266X.2017.17.003
血清可溶性肿瘤坏死因子样弱凋亡诱导因子水平与扩张型心肌病患者左心室重构的关系
Serum level of sTWEAK and its relationship with left ventricule remodeling in patients with dilated cardiomyopathy
摘要
Abstract
Objective To investigate the changes of serum soluble tumor necrosis factor-like weak inducer of apoptosis(sTWEAK)in patients with dilated cardiomyopathy(DCM)and its relationship with plasma N-terminal pro-natriuretic peptide(NT-proBNP)and left ventricular mass index(LVMI).Methods One hundred DCM patients(DCM group)and 60 patients without heart failure(control group)were enrolled.The levels of serum sTWEAK and NT-proBNP were determined by ELISA,and LVMI was measured by echocardiography.Results The level of serum sTWEAK in the DCM group was significantly lower than that in the control group,but the levels of NT-proBNP and LVMI were significantly higher than those in the control group(all P<0.05).The level of serum sTWEAK in the DCM group was not correlated with NYHA classification,but it was negatively correlated with NT-proBNP and LVMI(r=-0.524,r=-0.337,all P<0.05),and this correlation still existed after adjusting gender,age,body mass index,total cholesterol,low-density lipoprotein,heart rate,NYHA classification and so on.Multiple stepwise regression analysis showed that serum sTWEAK level was affected by LVMI in DCM patients.Conclusion The level of serum sTWEAK decreases in DCM patients and it could reflect the severity of left ventricular remodeling.关键词
扩张型心肌病/可溶性肿瘤坏死因子样弱凋亡诱导因子/N-末端脑钠肽前体/心室重构Key words
dilated cardiomyopathy/soluble tumor necrosis factor-like weak inducer of apoptosis/N-terminal pro-natriuretic peptide/ventricular remodeling分类
医药卫生引用本文复制引用
张杰,何飞,郭荣,赵菁,梁莹,王佳佳,李晓红,吴晓丹..血清可溶性肿瘤坏死因子样弱凋亡诱导因子水平与扩张型心肌病患者左心室重构的关系[J].山东医药,2017,57(17):7-9,3.基金项目
国家自然科学基金资助项目(81070445) （81070445）
河南省医学科技攻关计划项目(201403030,201403029). （201403030,201403029）
