山东医药2017，Vol.57Issue(17)：13-16,4.DOI:10.3969/j.issn.1002-266X.2017.17.005
2型糖尿病合并冠心病患者的心率变异性及其与心脏结构功能变化的关系
Heart rate variability in patients with type 2 diabetes and coronary heart disease and its relationship with cardiac structure function indexes
摘要
Abstract
Objective To observe the changes of heart rate variability(HRV)in patients with type 2 diabetes mellitus(T2DM),coronary heart disease(CHD),or T2DM and CHD,and its relationship with the index of cardiac structure function.Methods We chose 33 cases of patients with T2DM and CHD(T2DM combined with CHD group),32 patients with T2DM(T2DM group),32 patients with CHD(CHD group),and 31 cases of healthy controls(control group).The 24-hour dynamic electrocardiogram and echocardiography were performed to analyze the correlation of the time domain index of HRV,circadian variation and HRV index with cardiac structure function index.Results From comparing the four groups,the T2DM combined with CHD group had the highest incidence of HRV decrease,but the CHD group and T2DM group had no significant difference in the incidence of HRV decrease.HRV index of the T2DM combined with CHD group had no significant difference between awake state and sleeping state,but in the control group,every index of sleeping state was significantly higher than that of the awake state.Compared with the T2DM group and CHD group,left ventricular ejection fraction(LVEF)and E/A of the T2DM combined with CHD group decreased,but left ventricular end-diastolic diameter(LVEDD)and LA increased.Standard deviation of R-R intervals(SDNN)was negatively correlated with LA and LVEDD,but was positively correlated with LVEF and E/A.SDANN was negatively correlated with LVEDD,but was positively correlated with LVEF and E/A.SDNN index and LVEF was positively correlated.rMSSD was positively correlated with LVEF and E/A.Conclusions Patients with T2DM and CHD have the most serious autonomic nerve damage,and the heart rate variation of circadian rhythm is vanished.HRV can reflect the severity of the cardiac remodeling and cardiac function damage.关键词
心率变异性/2型糖尿病/冠心病/自主神经系统/昼夜节律/心脏结构功能Key words
heart rate variability/type 2 diabetes mellitus/coronary heart disease/autonomic nervous system/circadian rhythm/cardiac structure function分类
医药卫生引用本文复制引用
李静芳,张苏河,张东铭,辛雅萍,付艳芹..2型糖尿病合并冠心病患者的心率变异性及其与心脏结构功能变化的关系[J].山东医药,2017,57(17):13-16,4.基金项目
河南省医学科技攻关计划项目(201403091). （201403091）
