同济大学学报（医学版）2017，Vol.38Issue(2)：17-22,6.DOI:10.16118/j.1008-0392.2017.02.004
可降解JDBM支架与镍钛合金支架植入兔腹主动脉术后的对比研究
Comparison of biodegradable Mg alloy JDBM stent and nitinol stent implanted in abdominal aorta of rabbits
摘要
Abstract
Objective To compare the efficacy and safety of bare biodegradable magnesium alloy JDBM stent with bare nitinol stent implanted in abdominal aorta of rabbits.Methods Bare biodegradable magnesium alloy JDBM stents (JDBM stent,n =12) or bare nitinol stents (BMS group,n =12) were implanted in abdominal aorta of New Zealand white rabbits.At 14th,30th and 60th day after implantation,abdominal aortic angiography,artery elasticity and blood tests were performed.Results Angiography showed that all stents were patent with normal flow.No death,perforation,dissection,stent migration,in-stent thrombosis or restenosis were observed in either group.The level of blood platelets [(451.3 ± 47.4) × 109/L)] and serum NO [(109.7 ± 19.5)μmol] were significant higher in JDBM group in comparison with BMS group [(347.8 ±62.5) × 109/L,82.2 ± 23.2 μmol/L)],then returned to baseline at d30.The elasticity of arteries where implanted JDBM stents was recovered at d60 after operation,the stiffness parameter β in JDBM group was consistently better than that in BMS group.Conclusion The implantation of biodegradable magnesium alloy JDBM vascular stents in abdominal aorta of rabbits is effective and safe.The JDBM stent shows favorable biocompatibility in vivo and superiority in artery elasticity compared with nitinol stent.关键词
可降解支架/镁合金/血管成形术/腹主动脉/兔Key words
biodegradable stents/magnesium alloy/angioplasty and stenting/abdominal aortic artery/rabbit分类
医药卫生引用本文复制引用
谭晋韵,陈莉,余波,裴佳,袁广银,丁文江..可降解JDBM支架与镍钛合金支架植入兔腹主动脉术后的对比研究[J].同济大学学报（医学版）,2017,38(2):17-22,6.基金项目
上海市自然科学基金(15ZR1422600) （15ZR1422600）
