同济大学学报（医学版）2017，Vol.38Issue(2)：51-55,5.DOI:10.16118/j.1008-0392.2017.02.010
Irisin与急性冠脉综合征的相关性研究
Correlation of serum irisin level with acute coronary syndrome
摘要
Abstract
Objective To investigate the correlation between serum irisin level and acute coronary syndrome (ACS).Methods A total of 182 patients,including 102 males and 74 males,from Shanghai Tenth Peoples Hospital,Tongji University were enrolled in the study.According to the level of cTNT,they were divided into normal control group (cTNT ＜ 0.014 ng/ml),myocardial injury group (cTNT 0.015-0.05 ng/ml) and ACS group (cTNT ＞0.051 ng/ml).According to the responsible vessels,the ACS group was further divided into left anterior descending branch (LAD) lesion group and no left anterior descending branch lesion group.All the participants received questionnaire survey,physical examination,blood chemistry tests and serum irisin measurement.Univariate analysis,Student's t test and Person correlation were used for data analysis.Results Serum irisin levels were significantly increased in ACS group compared with control [(145.35 ±10.11) ng/ml vs (102.68 ±5.60) ng/ml,P ＜0.01].In ACS patients serum Irisin levels were higher in LAD lesions group than those in non-LAD lesion group [(123.86 ± 8.05) ng/ml vs (108.27 ± 5.72) ng/ml,P ＜ 0.05].Irisin was positively correlated with NT-proBNP,high-sensitivity c-reactive protein (hs-CRP) and fasting blood glucose (FBG) (r =0.259,P ＜0.01;r =0.445,P ＜ 0.01;r =0.179,P ＜ 0.05 respectively).Conclusion Serum irisin levels are increased in ACS patients,which might be used as a biomarker in prediction,diagnosis and treatment of ACS.关键词
鸢尾素/急性冠脉综合征/左前降支Key words
Irisin/acute cononary syndrome/left anterior descending branch分类
医药卫生引用本文复制引用
许小朋,赵逸凡,周顺萍,彭文辉,徐亚伟..Irisin与急性冠脉综合征的相关性研究[J].同济大学学报（医学版）,2017,38(2):51-55,5.基金项目
国家自然科学基金面上项目(81370391) （81370391）
