CYP2C19基因多态性与脑梗死患者氯吡格雷临床疗效的相关性研究OACSTPCD
Correlation between CYP2C19 gene polymorphisms and efficacy of clopidogrel in patients with cerebral infarction
目的 探究CYP2C19基因多态性与氯吡格雷治疗脑梗死患者疗效的相关性.方法 选取我院2012年1月至2015年1月的脑梗死患者200例.根据基因型分为高、中间、弱代谢型三组.统计口服氯吡格雷前、第1天、第6天、第8周患者的血小板聚集抑制率、美国国立卫生研究院脑卒中量表(National Institute of Health stroke scale,NIHSS)评分、日常生活能力评分(Activities of Daily Living,AD…查看全部>>
Objective To investigate the correlation between CYP2C19 gene polymorphisms and the efficacy of clopidogrel in patients with cerebral infarction.Methods Two hundred patients with cerebral infarction treated in our hospital from January 2012 to January 2015 were included in the study.The DNA was extracted from blood samples and the CYP2C19 gene polymorphisms were detected by PCR-RFLP.According to the genotypes of CYP2C19 gene,patients were divided into extens…查看全部>>
郑艳娥;黄敬;李菲;臧磊;王兴媛
同济大学医学院,上海200092同济大学附属同济医院分院内科,上海200092同济大学医学院,上海200092同济大学附属同济医院分院内科,上海200092同济大学附属同济医院分院内科,上海200092
医药卫生
脑梗死氯吡格雷CYP2C19基因多态性
cerebral infarctionclopidogrelCYP2C19gene polymorphisms
《同济大学学报（医学版）》 2017 (2)
60-64,5
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