同济大学学报（医学版）2017，Vol.38Issue(2)：65-68,4.DOI:10.16118/j.1008-0392.2017.02.013
短期持续正压通气对阻塞性睡眠呼吸暂停低通气综合征合并慢性肾脏疾病患者的影响
Effects of short-term continuous positive airway pressure ventilation on chronic kidney disease in patients with obstructive sleep apnea/hypopnea syndrome
吕颖 1刘熹 2张春燕 1余晨1
作者信息
- 1. 同济大学附属同济医院肾内科,上海200065
- 2. 宁波大学医学院附属医院肾内科,浙江宁波315000
- 折叠
摘要
Abstract
Objective To investigate the effects of short-term continuous positive airway pressure (CPAP) on chronic kidney disease (CKD) in patients with obstructive sleep apnea/hypopnea syndrome(OSAHS).Methods Thirty nine OSAHS patients complicated with CKD were enrolled in the study.According to the apnea-hypopnea index (AHI) patients received CPAP treatment at night on the basis of standard treatment.The factors influencing the estimated glomerular filtration rate(eGFR)and urinary albumin/creatinine ratio(UACR) were analyzed by multiple linear regression analysis;and the effect on short-term CPAP treatment on renal function of patients was also analyzed.Results There were 23 cases of severe OSAHS patients and 16 cases of moderate OSAHS cases.Multiple linear regression analysis showed that eGFR was negatively correlated with AHI(β =-0.436,P=0.001),age(β=-0.319,P=0.003) andUACR(β=-0.339,P=0.005);AHI,age and UACR were independent risk factors for decreased eGFR in OSAHS patients with CKD.UACR was negatively correlated with average pulse oxygen saturation (ASpO2) (β =-0.492,P ＜ 0.001) and positively correlated with diastolic blood pressure (β =-0.319,P =0.003);ASpO2 and diastolic blood pressure were independent risk factors of the increased UACR.After CPAP treatment,the serum creatinine and eGFR were improved in all patients,while the UACR and urinary α1-MG were significantly improved in severe OSAHS patients.Conclusion The results indicate that short-term CPAP treatment can benefit the OSAHS patients complicated with CKD.关键词
慢性肾脏病/持续正压通气/阻塞性睡眠呼吸暂停低通气综合征Key words
chronic kidney disease/continuous positive airway pressure/obstructive sleep apnea hypopnea syndrome分类
医药卫生引用本文复制引用
吕颖,刘熹,张春燕,余晨..短期持续正压通气对阻塞性睡眠呼吸暂停低通气综合征合并慢性肾脏疾病患者的影响[J].同济大学学报（医学版）,2017,38(2):65-68,4.
