同济大学学报（医学版）2017，Vol.38Issue(2)：84-88,94,6.DOI:10.16118/j.1008-0392.2017.02.017
中老年2型糖尿病患者血清25-羟维生素D水平及相关因素分析
Serum 25-hydroxy vitamin D level and its influencing factors in middle-old aged patients with type 2 diabetes
摘要
Abstract
Objective To investigate the serum 25-hydroxy vitamin D level and its influencing factors in middle-old aged patients with type 2 diabetes (T2DM).Methods Total 548 middle-old aged patients with type 2 diabetes(280 males and 268 females) and 120 healthy subjects(60 males and 60 females) were enrolled in the study.Fasting blood samples were collected and serum 25-hydroxy vitamin D,Ca,P,FINS,FPG,HbA1 c,TG,TC,LDL-C,HDL-C were measured.Results Serum 25-hydroxy vitamin D in diabetic patients was (36.89 ± 16.82)nmol/L,and that in healthy controls was (45.84 ± 17.68) nmol/L (P ＜ 0.05).The mean serum 25-hydroxy vitamin D level in male diabetic patients was higher than that in female patients [(38.09 ± 16.58)nmol/L vs (35.63 ± 16.26)nmol/L,P ＜ 0.05].Serum 25-hydroxy vitamin D level in male patients was significantly higher than female patients in all age group except 50-59 (P ＜ 0.05).In male patients,25-hydroxy vitamin D level in age group ≥ 70 was the highest,that in age group 40-49 was the lowest,there were significant difference among different age group (F =17.68,P ＜ 0.01).In female patients,25-hydroxy vitamin D level in age group ≥70 was the highest,that in age group 40-49 was the lowest,there were significant difference among different age groups (F =13.43,P ＜ 0.01).The 25-hydroxy vitamin D deficiency rate in T2DM patients was 58.39％ (60.82％ for female and 56.07％ for male,P ＜0.01).25-hydroxy vitamin D was positively correlated with Ca (r =0.072)and HOMA-β (r =0.406) (both P ＜ 0.05),and negatively correlated with BMI (r =-0.574),P (r =-0.098),TC (r =-0.401),TG(r=-0.325),LDL-C(r=-0.457),FPG(r=-0.238),HbA1c(r=-0.363) and HOMA-IR(r =-0.251) (all P ＜ 0.05).Conclusion Serum 25-hydroxy vitamin D concentration in middle-old aged patients with type 2 diabetes is significantly lower than in healthy subjects,and influenced by age,gender,serum Ca,P,blood glucose,cholesterol and pancreas islet function.关键词
2型糖尿病/中老年/25-羟维生素D/影响因素Key words
type 2 diabetes/middle-aged and elderly/25-hydroxy vitamin D/influence factor分类
医药卫生引用本文复制引用
曾瑞翔,张冰雨,舒晓亮,雷涛..中老年2型糖尿病患者血清25-羟维生素D水平及相关因素分析[J].同济大学学报（医学版）,2017,38(2):84-88,94,6.基金项目
国家“八六三”高技术研究发展计划(2014AA022304) （2014AA022304）
