生物加工过程2017，Vol.15Issue(3)：29-35,7.DOI:10.3969/j.issn.1672-3678.2017.03.006
色谱法提取柠檬酸的除杂工艺优化
Optimizing chromatography extraction decontaminate impurities of citric acid
摘要
Abstract
In order to improve decontamination methods used in chromatographic citric acid extraction processes,a granular activated carbon GH-11 and a 001×7 cation exchange resin were used to pretreat and remove impurities from citric acid fermentation broth.The effects of two different treatment processes,decolorizing-decationizing and decationizing-decolorizing,were analyzed,whereby the piping distribution of the continuous ionic exchange (ISEP) extraction system was optimized.The results showed that,compared with the decolorizing-decationizing process,the decationizing-decolorizing process was better.This method increased 7.2% in average handling capacity,with concomitant 6.25%,35.3% and 29.5% decreases in acid consumption,decolorization wastewater and decationization wastewater compared to the decolorizing-decationizing process,respectively.When handling capacity was increased from 5 L to 80 L,the average transmission rate of the citric acid solution increased by 2.5%.The purity of the citric acid solution was increased from 87.4% to 88.9% without sacrificing throughput.By prolonging the system retention time and optimizing the feed flow rate,the adsorption capacity of the resin was increased and the consumption of auxiliary materials (e.g.,sulfuric acid,liquid ammonia) was reduced,which lowered production costs.In addition,the easily-carbonized impurities decreased from 5.0 to 3.0 when citric acid solution was treated by our decationizing-decolorizing process and ISEP extraction system.关键词
柠檬酸/色谱法/除杂/活性炭/离子交换树脂Key words
citric acid/chromatography/decontaminate/activated carbon/ion exchange resin分类
生物科学引用本文复制引用
满云,彭钢,陶惟一,郭东升,李秀娟,俞亚东,黄和..色谱法提取柠檬酸的除杂工艺优化[J].生物加工过程,2017,15(3):29-35,7.基金项目
国家自然科学基金(21506096、21476111) （21506096、21476111）
国家高技术研究发展计划(2013AA020302) （2013AA020302）
江苏省自然科学基金(BK20131405) （BK20131405）
农业部农产品加工重点实验室开放课题(2015011) （2015011）
江苏高校优势学科建设工程 （）
