应用化学2017，Vol.34Issue(5)：534-540,7.DOI:10.11944/j.issn.1000-0518.2017.05.160286
N-甲基吡咯烷酮作为一碳合成子在曼尼希反应中的应用
Application of N-Methyl-2-pyrrolidinone as One Carbon Synthon in Mannich Reactions
摘要
Abstract
With acetophenone derivatives as raw materials, we reported the application of N-methyl-2-pyrrolidone as one carbon synthon to replace formaldehyde analogues in the Mannich reaction.Under optimal reaction conditions, a series of mannich base derivatives were obtained with 46%~93% yield.This reaction shows a broad substrate scope and good functional groups compatibility.The preliminary mechanism of the reaction was also studied.关键词
曼尼希碱/N-甲基吡咯烷酮/一碳合成子/C-C键形成/C-N键形成Key words
Mannich base/N-methyl-pyrrolidinone/one carbon synthon/C-C bond formation/C-N bond formation分类
化学化工引用本文复制引用
王薪,孙凯..N-甲基吡咯烷酮作为一碳合成子在曼尼希反应中的应用[J].应用化学,2017,34(5):534-540,7.基金项目
国家自然科学基金资助项目(U1504210),吉林省有机功能分子设计与合成重点实验室资助项目(130028651) （U1504210）
Supported by the National Natural Science Foundation of China(No.U1504210), Funds of the Key Laboratory of Organic Functional Molecule Design and Synthesis of Jilin Province(No.130028651) （No.U1504210）
