应用化学2017，Vol.34Issue(5)：541-549,9.DOI:10.11944/j.issn.1000-0518.2017.05.160191
六氢-1H-吡咯并[3,4-d]嘧啶衍生物的合成及抗肿瘤活性
Synthesis and Antitumor Activity of Hexahydro-1H-pyrrolo [3,4-d] Pyrimidine Derivatives
摘要
Abstract
Using maleic anhydride as the starting material, hexahydro-1H-pyrrolo[3,4-d] pyrimidine derivatives were synthesized.The structures of all compounds were characterized by 1H NMR, 13C NMR, ESI-MS and elemental analysis.Their antitumor activities against Bel-740 human liver cancer cells were determined by the 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT) assay.The results indicate that these compounds have a certain inhibitory activity in Bel-740 human liver cancer cells, and the inhibitory activity of compounds 9d and 9g reach the average level.关键词
顺丁烯二酸酐/库尔提斯重排/六氢-1H-吡咯并[3,4-d]嘧啶衍生物/抗肿瘤活性Key words
maleic anhydride/curtius rearrangement/hexahydro-1H-pyrrolo [3/4-d] pyrimidine derivatives/antitumor activity分类
化学化工引用本文复制引用
李娜,李辉..六氢-1H-吡咯并[3,4-d]嘧啶衍生物的合成及抗肿瘤活性[J].应用化学,2017,34(5):541-549,9.基金项目
河南省产学研项目(132107000035) （132107000035）
Supported by the Industry, University, Research Project of He′nan(No.132107000035) （No.132107000035）
