中国临床药理学与治疗学2017，Vol.22Issue(4)：439-442,4.
克林霉素耐药金黄色葡萄球菌检出率与抗菌药物使用的相关性分析
Correlation between detection rate of clindamycin-resistant Staphylococcus aureus and utilization of antibacterial drugs
摘要
Abstract
AIM:To provide information for reasonable clinical application of antibacterial drugs,the partial least squares (PLS) regression models were established for analyzing the correlation between detection rate of clindamycin-resistant Staphylococcus aureus (CRSA) and utilization of antibacterial drugs.METHODS:The PLS regression models were established with the defined daily doses (DDDs) of antibacterial drugs as independent variables and the detection rates of CRSA with same and different periods as dependent variables.The lag between detection rates of CRSA and utilization of antibacterial drugs were investigated.The antibacterial drugs,which were highly correlated with the detection rate of CRSA,were screened according to the variable importance (VIP) values.RESULTS:The detection rate of CRSA lagged about two quarters behind the utilization of antibacterial drugs,and was significantly positively correlated with the DDDs of cefoperazone/sulbactam,azithromycin and cefuroxime.CONCLUSION:It was effective to employ PLS regression algorithm to simultaneously analyze the correlation between detection rate of CRSA and utilization of multiple antibacterial drugs.This research provided a new scientific tool for the investigation of CRSA.关键词
偏最小二乘回归/抗菌药物/用药频度/克林霉素耐药金黄色葡萄球菌Key words
partial least squares regression/antibacterial drugs/defined daily doses/clindamycin-resistant Staphylococcus aureus分类
医药卫生引用本文复制引用
蒋程,吕健刚,李芳琼,叶佐武,鲁春芳,李功华..克林霉素耐药金黄色葡萄球菌检出率与抗菌药物使用的相关性分析[J].中国临床药理学与治疗学,2017,22(4):439-442,4.基金项目
浙江省公益技术应用研究计划项目(2016C33127) （2016C33127）
浙江省中医药科技计划项目(2015ZQ007) （2015ZQ007）
浙江省药学会医院药学专项科研资助项目(2014ZYY10) （2014ZYY10）
