中国临床医学2017，Vol.24Issue(2)：199-203,5.DOI:10.12025/j.issn.1008-6358.2017.20161132
高血压患者豆纹动脉数量减少与局部脑代谢物变化的相关性
Correlation between the reduction in lenticulostriate arteries caused by hypertension and changes in brain metabolism
摘要
Abstract
Objective:To evaluate the correlation between changes in brain metabolism and the reduction in small arteries in patients with hypertension.Methods:Fifty patients with hypertension and fifty volunteers without hypertension were enrolled.The two groups underwent 3T 3D time of flight MR angiography (MRA) and Single voxel proton MR spectroscopic (MRS).The numbers of lenticulostriate arteries (LSAs) and the ratios of Nacetylaspartate to creatine (NAA/Cr), myoinositol to creatine (MI/Cr), and choline to creatine (Cho/Cr) on the basal ganglia regions were calculated.Results:The average total number of LSA stems on both sides in patients with hypertension and volunteers without hypertension was 5.12±0.98 and 6.10±0.95, respectively (P<0.000 1).The NAA/Cr ratio decreased according to a reduction in the number of LSAs in the hypertension group, which was significantly reduced when the number of LSAs was 3 or fewer.Conclusions:Hypertension can lead to a statistically significant reduction in NAA/Cr ratio on the basal ganglia regions when the number of LSAs decreases to a certain extent.关键词
高血压病/豆纹动脉/脑代谢/NAA/Cr比值Key words
hypertension/lenticulostriatarteries/brain metabolism/NAA/Cratio分类
医药卫生引用本文复制引用
潘海宾,李跃华,李晓兵,魏小二,汪璇..高血压患者豆纹动脉数量减少与局部脑代谢物变化的相关性[J].中国临床医学,2017,24(2):199-203,5.基金项目
国家自然科学基金 (81471656),上海市自然科学基金(14ZR1432100),上海市人才发展基金(201555).Supported by National Natural Science Foundation of China(81471656), Shanghai Municipal Natural Science Foundation (14ZR1432100), and Shanghai Talent Development Fund (201555). （81471656）
