中国临床医学2017，Vol.24Issue(2)：290-292,3.DOI:10.12025/j.issn.1008-6358.2017.20160721
阻塞性睡眠呼吸暂停低通气综合征患者体内相关炎症因子水平改变及其与嗜睡情况的相关性分析
Changes in levels of inflammatory factors in patients with obstructive sleep apnea hypopnea syndrome and their correlation with sleepiness
摘要
Abstract
Objective:To analyze the correlation between inflammatory factors and sleepiness A total of scores in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods:Fourty patients with obstructive sleep apnea hypopnea syndrome treated in the No.463 Hospital of PLA were selected as the OSAHS group.40 healthy subjects were selected as the healthy group.Sleepiness scores were obtained by using the Epworth Sleepiness Scale (ESS) in the form of questions and answers.The morning fasting blood samples were taken, changes in the levels of serum tumor necrosis factor-alpha(TNF-α), serum malondialdehyde (MDA), serum glutathione (GSH) and serum superoxide dismutase (SOD) and their correlation with sleepiness were analyzed.Results:The ESS score, serum TNF-α and serum MDA of the OSAHS group were higher than those of the healthy group (P<0.05).Serum GSH and serum SOD of the OSAHS group were lower than those of the healthy group (P<0.05).The ESS scores of both groups were correlated with serum TNF-α(r=0.815), MDA (r=0.528), GSH (r=-0.433) and SOD (r=-0.607,P<0.01).Conclusions:The serum TNF-α, MDA, GSH, and SOD levels of OSAHS patients change, and they were related to sleepiness.关键词
阻塞性睡眠呼吸暂停/嗜睡评分/肿瘤坏死因子α/丙二醛/谷胱甘肽/超氧化物歧化酶Key words
obstructivsleep apnea/sleepinesscale/tumonecrosifactoα/malondialdehyde/glutathione/superoxiddismutase分类
医药卫生引用本文复制引用
刘杰峰,庞剑..阻塞性睡眠呼吸暂停低通气综合征患者体内相关炎症因子水平改变及其与嗜睡情况的相关性分析[J].中国临床医学,2017,24(2):290-292,3.基金项目
全军"十二五"科研课题(CWS11J207).Supported by the 12th Five-Year Issue of the PLA (CWS11J207). （CWS11J207）
