中国普通外科杂志2017，Vol.26Issue(5)：556-560,5.DOI:10.3978/j.issn.1005-6947.2017.05.004
多灶性甲状腺乳头状癌的临床病理及颈淋巴结转移特征
Clinicopathologic and neck metastasis features of multifocal papillary thyroid cancer
摘要
Abstract
Objective: To investigate the clinicopathologic and neck metastasis features of multifocal papillary thyroid cancer (PTC). Methods: The clinical data of 323 patients undergoing surgical treatment in Department of Thyroid Surgery, the First Alliated Hospital of Zhengzhou University from June 2016 to October 2016, who had pathologically confirmed PTC were retrospectively analyzed. Of the patients, 148 cases had multifocal PTC and 175 cases were unifocal PTC. Results: No significant difference was seen in age, gender and maximal tumor diameter between patients with multifocal PTC and unifocal PTC (allP>0.05), but the former showed higher incidence of central neck metastasis (P<0.001), lateral neck metastasis (P=0.028), and extrathyroidal extension (P<0.001) than those in the latter.Among patients with multifocal PTC, the incidence of central neck metastasis (P=0.010), lateral neck metastasis (P=0.018) and extrathyroidal extension (P=0.020) in cases with 3 or more lesions were significantly increased compared with cases with 2 lesions. Multivariate analysis showed that the maximal tumor diameter (P=0.005) and tumor number (P=0.006) were independent risk factors for central neck metastasis in multifocal PTC. Conclusion: Compared to unifocal PTC, multifocal PTC has relatively higher invasiveness, is more likely to develop metastasis and invasion, for which total thyroidectomy with central compartment neck dissection is recommended as the standard treatment, and lateral neck dissection should be strongly considered in those with lateral neck lymph node enlargement.关键词
甲状腺肿瘤/癌,乳头状/淋巴转移Key words
Thyroid Neoplasms/Carcinoma,Papillary/Lymphatic Metastasis分类
医药卫生引用本文复制引用
殷德涛,韩飏,张亚原,李红强,王勇飞,柳桢,苌群刚..多灶性甲状腺乳头状癌的临床病理及颈淋巴结转移特征[J].中国普通外科杂志,2017,26(5):556-560,5.基金项目
国家自然科学基金资助项目(81372863) （81372863）
郑州市科技计划(领军人才)基金资助项目(131PLJRC676). （领军人才）
