中国人兽共患病学报2017，Vol.33Issue(4)：293-299,7.DOI:10.3969/j.issn.1002-2694.2017.04.001
盖塔病毒分子进化及其迁徙
Phylogenctics of Getah virus and its migration
摘要
Abstract
In order to investigate the molecular evolution and spatio-temporal migration of Getah viruses (GETV) isolated around the world,the nucleotide and deduced amino acid sequence of GETVs were analyzed and phylogenetic trees were constructed by using informatics software including ClustalX1.83,MegaAlign,GeneDOC and Mega6.0.The Bayesian Stochastic Search Variable Selection (BSSVS) program in the BEAST v 1.8.1 software package was used to analyze the spatial dynamics of the Getah virus.Results showed that the full-length of Getah virus E2 gene consists of 1 266 nueleotides,encoding 422 amino acids.And the homology of nucleotide and amino acid were 94.5％ 100％ and 96.4％ 100％ respectively.The molecular evolution analysis revealed that there were no species and geographical distribution difference existing among GETV host animals (e.g.horses and pigs) and vectors (e.g.mosquitoes).Bioinformatics analysis showed that GETV originated in Malaysia,then it was spread to Japan,China,South Korea,Mongolia,Russia,etc.GETV E2 gene was relatively stable since GETV was first isolated in 1955.The differences of species and geographical distribution did not exist among GETV host animals and vectors,and the virus has spread from tropical regions to Eurasian continent.Thus,strengthening the detection and monitoring of GETV and its infections in humans and livestock is critical.关键词
盖塔病毒/分子进化/时空迁徙Key words
Getah virus/molecular evolution/spatial and temporal migration分类
医药卫生引用本文复制引用
李元元,王桂琴,梁国栋,刘红,李晓龙,付士红,高晓艳,雷雯雯,吕志,何英,王环宇..盖塔病毒分子进化及其迁徙[J].中国人兽共患病学报,2017,33(4):293-299,7.基金项目
国家自然科学基金重大项目(No.81290342)资助.Supported by the National Natural Science Foundation of China (No.81290342). （No.81290342）
