中国现代医学杂志2017，Vol.27Issue(8)：17-20,4.DOI:10.3969/j.issn.1005-8982.2017.08.004
前列腺素E1后处理对大鼠移植肝缺血再灌注损伤的保护作用
Protection effect of post- processing prostagandin E1 in rat liver transplantation ischemia- reperfusion injury
摘要
Abstract
Objective To study the protective effects and mechanisms of prostaglandin E1 (PGE1) post-conditioning in liver graft ischemia-reperfusion injury. Methods The liver transplantation rat model was used as ischemia-reperfusion injury animal model. The rats were randomly divided into three groups: ischemic reperfusion injury group (IRI), postconditional PGE1 treated group (PGE1) and sham operated group (S). The liver functional tests, SOD, MDA, TNF-α expression level and the histology were checked at 2 h and 6 h after reperfusion. Results The ALT, AST, MDA in serum and TNF-α expression level in liver were significantly lower in PGE1 group than in IRI group ( <0.05), the SOD was higher in the PGE1 group ( <0.05). The tissue damage was significantly decreased in PGE1 group. Conclusions Prostaglandin E1 postconditioning has significant protective effect in ischemia-reperfusion injury, and part of those benefit effects dependent on decreased TNF-α expression level and increased SOD production.关键词
肝移植/缺血再灌注损伤/药物后处理/前列腺素E1Key words
liver transplantation/ischemic reperfusion injury/pharmacological postconditioning/prostaglandin E1分类
医药卫生引用本文复制引用
王玉柱,明英姿..前列腺素E1后处理对大鼠移植肝缺血再灌注损伤的保护作用[J].中国现代医学杂志,2017,27(8):17-20,4.基金项目
河南省科技攻关计划资助项目(No:162102310303) （No:162102310303）
