中国现代医学杂志2017，Vol.27Issue(8)：32-37,6.DOI:10.3969/j.issn.1005-8982.2017.08.007
三七粉对四氯化碳(CCl4)诱导的大鼠慢性肝损伤的保护作用
Protective effect of powder on CCl4-induced chronic liver injury in rats
摘要
Abstract
Objective To investigate the protective effects of powder on chronic liver injury and liver fibrosis induced by CCl4. Methods The model of CCl4-induced chronic liver injury and fibrosis in SD rats was established by hypodermic injection of 10% CCl4 in peanut oil. Biochemical criteria were measured respectively, including ALT, AST, IL-1, IL-6, IL-8 and TNF-α in serum, and MDA, SOD, GSH, GSH-PX, Cyt.P450 and Cyt.b5 in liver homogenate. And HE dyeing, histopathological changes in liver were observed on the effects of powder through the microscope. Results The levers of ALT, AST were decreased, and the activity of Cyt.P450 and Cyt.b5 enzyme was promoted. The levels of SOD, GSH and GSH-Px were enhanced, and the level of MDA were reduced, and the activity of IL-1, IL-6, IL-8 and TNF-α was inhibited observably in liver. Conclusions powder has been proved to possess significant effects on the liver fibrosis and injury induced by CCl4.关键词
三七粉/四氯化碳/肝纤维化/肝损伤/保护作用Key words
powder/CCl4/liver fibrosis/liver injury/protective effect分类
医药卫生引用本文复制引用
董婧婧,刘艳菊,陈祥胜,付伟,李鑫..三七粉对四氯化碳(CCl4)诱导的大鼠慢性肝损伤的保护作用[J].中国现代医学杂志,2017,27(8):32-37,6.基金项目
国家中医药管理局2015年中医药部门公共卫生专项资金(中药科技类) （中药科技类）
