中国现代医学杂志2017，Vol.27Issue(8)：38-42,5.DOI:10.3969/j.issn.1005-8982.2017.08.008
锌指蛋白217在结肠癌组织中的表达及其临床意义
Expression and clinical significance of ZNF217 in colon cancer
秦豫培 1胡阳黔1
作者信息
- 1. 湖北医药学院附属东风总医院 消化内科,湖北 十堰 442000
- 折叠
摘要
Abstract
Objective To explore the expression of ZNF217 in tissues of colon cancer (CRC), investigate the association of the expression levels of ZNF217 and clinicopathological features of CRC patients, and analyze the relevance of ZNF217 and survival and prognosis of CRC patients. Methods Expressions of ZNF217 were analyzed by immunohistochemistry in 84 CRC patients. Spearman's rank test, K-M survival curves, and Cox proportional hazards risk were conducted to analyze the clinical relevance of ZNF217 in CRC. Results Immunohistochemistry revealed that the positive rate of ZNF217 was upregulated in CRC tissues compare with adjacent tissues. Spearman rank correlation showed that positive ZNF217 expression was significantly associated with TNM stage, lymph node status and venous invasion of CRC patients. Kaplan-Meier curves showed that positive ZNF217 expression was inversely correlated with 5 years overall and progression-free survival time of CRC patients. Cox proportional hazards risk analysis revealed that ZNF217 was an independent prognostic factor for CRC. Conclusions ZNF217 expression is upregulated in tissues of CRC, and ZNF217 is a potential survival and prognosis biomarker in CRC.关键词
锌指蛋白217/结肠癌/生存/预后Key words
ZNF217/colon cancer/survival/prognosis分类
医药卫生引用本文复制引用
秦豫培,胡阳黔..锌指蛋白217在结肠癌组织中的表达及其临床意义[J].中国现代医学杂志,2017,27(8):38-42,5.
