中国现代医学杂志2017，Vol.27Issue(8)：47-50,4.DOI:10.3969/j.issn.1005-8982.2017.08.010
激素联合免疫抑制剂对紫癜性肾炎患儿血清白介素16和18水平的影响
Research on effect of corticosteroid combined with immunosuppressor on children with Henoch-Schonlein purpura nephritis
何盾 1吴芳兰 2陈立华 2杨曼琼3
作者信息
- 1. 湖南省常德市第一人民医院 皮肤科,湖南 常德 415003
- 2. 湖南省长沙市第一医院 检验科,湖南 长沙 410005
- 3. 湖南省人民医院 儿科,湖南 长沙 410005
- 折叠
摘要
Abstract
Objective To study the effect of corticosteroid combined with immunosuppressor on children with Henoch-Schonlein purpura nephritis (HSPN). Methods A total of 60 patients with HSPN were collected and divide into group A (corticosteroid combined with immunosuppressor) and group B (conventional treatment) according to condition of patients. Serum levels of IL-16 and IL-18 of all patients were detected by ELISA. Results The serum level of IL-16 and IL-18 in group A was higher than those in group B ( <0.05). After treated by corticosteroid combined with immunosuppressor, the serum levels of IL-16 and IL-18 were sig-nificantly lower than those before treatment among group A. Conclusions IL-16 and IL-18 may be involved in the development of HSPN. Corticosteroid combined with immunosuppressor may play a therapeutic role through suppressing IL-16 and IL-18.关键词
紫癜性肾炎/皮质类固醇激素/免疫抑制剂/IL-16/IL-18Key words
Henoch-Schonlein purpura nephritis (HSPN)/corticosteroid/immunosuppressor/IL-16/IL-18分类
医药卫生引用本文复制引用
何盾,吴芳兰,陈立华,杨曼琼..激素联合免疫抑制剂对紫癜性肾炎患儿血清白介素16和18水平的影响[J].中国现代医学杂志,2017,27(8):47-50,4.
