中国现代医学杂志2017，Vol.27Issue(8)：51-54,4.DOI:10.3969/j.issn.1005-8982.2017.08.011
急性高容量血液稀释对脑动脉瘤夹闭患者认知功能、血清S-100β和氧代谢的影响
Effect of acute hypervolemic hemodilution on cognitive function, serum S-100β and oxygen metabolism in patients with cerebral aneurysm clipping
摘要
Abstract
Objective To explore effect of acute hypervolemic hemodilution (AHH) on cognitive function, serum S-100β and oxygen metabolism in patients with cerebral aneurysm clipping. Methods A total of 60 patients with clipping of cerebral aneurysm were selected and randomly divided into AHH group and control group, each of 30 cases. All the operations were performed under general anesthesia with tracheal intubation. The AHH group was performed AHH at the same time. The value of saturation jugular venous oxygen (SjvO2), cerebral arteriovnous oxygen difference (AVDO2) and S-100β at the following time points were collected:immediately after anesthesia induction (T0), blood dilution 15 min (T1), blood dilution 60 min (T2), at the end of surgery (T3), postoperative 3 d (T4). Cognitive functions (MMSE and LOTCA) preoperatively and 7 d post-operatively in patients were compared. Results Intraoperative fluid input, blood loss, urine volume, operation time had no significant difference between the two groups ( >0.05). SjvO2, AVDO2, S-100β, in different time points had statistically difference ( <0.05), and the difference was statistically significant between two groups ( <0.05). MMSE and LOTCA had no statistically difference in different points ( > 0.05). Conclusions Effect of AHH on cerebral oxygen metabolism in patients with cerebral aneurysm clipping causes transient brain injury, but has no significant effect on the cognitive function of patients.关键词
急性高容量血液稀释/脑动脉瘤/认知功能/S-100β/氧代谢Key words
acute hypervolemic hemodilution/brain aneurysm/cognitive function/S-100β/oxygen metabolism分类
医药卫生引用本文复制引用
李航,王飞,文远超,蒋其俊,甘正凯,余云糊..急性高容量血液稀释对脑动脉瘤夹闭患者认知功能、血清S-100β和氧代谢的影响[J].中国现代医学杂志,2017,27(8):51-54,4.基金项目
贵州省卫生厅科学技术课题(No:Gzwkj2013-1-059) （No:Gzwkj2013-1-059）
