中国现代医学杂志2017，Vol.27Issue(8)：66-70,5.DOI:10.3969/j.issn.1005-8982.2017.08.014
氨甲环酸局部注射对初次单侧全膝关节置换术后失血量的影响
Effect of tranexamic acid topically using combine with high va-cuum wound drainage system to blood loss on postoperative after unilateral primary total knee arthroplasty
李晓声 1李晶 2陈铁柱 1蒋志达 1朱健1
作者信息
- 1. 湖南省人民医院 关节外科,湖南 长沙 410005
- 2. 南华大学 湖南 衡阳 421001
- 折叠
摘要
Abstract
Objective To discuss the effect of combined usage of tranexamic acid (TXA) topically and high vacuum wound drainage system (REDON SET) to the blood loss on postoperative after unilateral primary total knee arthroplasty. Methods From Dec 2013 to Aug 2016, 60 patients suffered from osteoarthitis arthritis (OA) underwent primaral total knee arthroplasty (TKA) were collected. According to whether injected the TXA topically or not before closure, patients were divided into two groups. Group A (experimental group) was treated with topical injection of the TXA 10 ml (1.0 g) combined with Redon Set before closure. Group B (blank group) was treated with topical injection of the saline (10 ml) combined with Redon Set before closure. The volume of drainage and hemoglobin after operation, pre-operation and first, fourth, seventh day post-operatively and total blood loss were recorded. The rates of blood transfusion, transfusion volume and rate of the incidence of deep vein thrombosis were compared. Results Compared with group B, the total drainage volume, the hidden blood loss, total blood loss in 24 h after operation in group A had statically significant difference ( <0.05). The hemoglobin pre-operation and HCT in two groups had no statistically significant ( >0.05), but the hemoglobin and HCT in the first, fourth, seventh days postoperatively had significant difference ( <0.05). The rate of blood transfusion and transfusion volume in the group A were less than those in group B ( <0.05). The prevalence of throboembolic complications were 16.67%, 10.00% ( >0.05) respectively. Conclusions Topical injection of the TXA combined with Redon Set is effective for reducing postoperative blood loss and transfusion requirement without increasing prevalence of throboembolic complications in the unilateral primary total knee arthroplasty.关键词
全膝关节置换术/氨甲环酸/术后出血/局部注射/高负压引流瓶Key words
total knee arthroplasty/ranexamic acid/postoperative bleeding/topical injection/high vacuum wound drainage system分类
医药卫生引用本文复制引用
李晓声,李晶,陈铁柱,蒋志达,朱健..氨甲环酸局部注射对初次单侧全膝关节置换术后失血量的影响[J].中国现代医学杂志,2017,27(8):66-70,5.
