中国现代医学杂志2017，Vol.27Issue(8)：80-84,5.DOI:10.3969/j.issn.1005-8982.2017.08.017
脑出血患者外周血中性粒细胞/淋巴细胞和血小板/淋巴细胞比值的临床意义
Clinical significance of neutrophils/lymphocyte and platelet/lymphocyte ratio of peripheral blood in patients with intracerebral hemorrhage
陶冶 1薛维爽 1滕伟禹1
作者信息
- 1. 中国医科大学附属第一医院 老年神经内科,辽宁 沈阳 110001
- 折叠
摘要
Abstract
Objective To study the clinical significance of neutrophils/lymphocyte and platelet/lymphocyte ratio of peripheral blood in patients with intracerebral hemorrhage. Methods 363 patients with spontaneous cerebral hemorrhage and 95 cases of physical examination were randomly selected as cerebral hemorrhage group and the control group. The NLR, PLR in two groups and in patients with different degree of nerve function defect were compared. Subjects working curves (ROC) was calculated, and the area under curve was used to evaluate the diagnostic value of every index. NLR, PLR in survival group and death group were compared after the follow-up of 90 days' onset. Results Both the NLR, PLR were significantly higher in patients with cerebral hemorrhage than in control group, the difference was statistically significant ( <0.05). The NLR and PLR level had no statistically difference in hypertension cerebral hemorrhage group and non-hypertension cerebral hemorrhage group ( >0.05). The area under the ROC curve of NLR and PLR were 0.887 and 0.635. There was no statistical difference of NLR and PLR in mild neurologic function defect group and moderate group ( >0.05). The levels of NLR and PLR were significantly higher with statistically significant in severe neurologic function defect group and moderate or mild group ( < 0.05). NLR had no statistically significant difference between survival patients and death patients ( >0.05), while a statistically significant difference was found in PLR between two groups ( <0.05). When patients divided into two groups on the basis of a PLR level cut-off value of 157 based on receiver operating characteristic (ROC) curve, the patients with high-PLR values had worse functional outcomes (mRS >3) compared with the patients with low- PLR values ( =0.002, at third month). Conclusions Both the NLR, PLR are significantly higher in patients with cerebral hemorrhage than in control group. The diagnostic value of NLR is higher than the PLR. NLR may be associated with patients in the degree of acute nerve function defect, while PLR may be associated with the prognosis of nerve function.关键词
脑出血/中性粒细胞/淋巴细胞比值/血小板/淋巴细胞/神经功能缺损程度/预后Key words
cerebral hemorrhage/neutrophils/lymphocyte ratio/platelet/lymphocytes/degree of nerve function defect/prognosis分类
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陶冶,薛维爽,滕伟禹..脑出血患者外周血中性粒细胞/淋巴细胞和血小板/淋巴细胞比值的临床意义[J].中国现代医学杂志,2017,27(8):80-84,5.
