中国药房2017，Vol.28Issue(15)：2063-2065,3.DOI:10.6039/j.issn.1001-0408.2017.15.14
紫杉醇致肌肉酸痛发生情况分析及治疗
Analysis and Treatment of Paclitaxel-induced Muscle Soreness
胡丽丽 1董超 1王来成 1尹弟 2朱正秋 3高超 3黄广清 3李晓2
作者信息
- 1. 徐州医科大学附属医院药学部,江苏 徐州 221006
- 2. 徐州医科大学药学院,江苏 徐州 221006
- 3. 徐州医科大学附属医院肿瘤内科,江苏 徐州 221006
- 折叠
摘要
Abstract
OBJECTIVE:To observe the occurrence of paclitaxel(PTX)-induced muscle soreness and therapeutic efficacy and safety of diclofenac sodium. METHODS:Among 84 patients with malignant tumor receiving PTX chemotherapy,56 patients suf-fered from PTX-induced muscle soreness,among which 22 female patients suffered from medium and severe muscle soreness and then were randomly divided into group A and B,with 11 cases in each group. Group A was given Diclofenac sodium sustained-re-lease tablet 75 mg orally,once a day;group B was given Paracetamol and tramadol hydrochloride tablets one tablet orally,once a day,and then given Promethazine hydrochloride injection 100 mg subcutaneously,2-3 times a day when muscle soreness could not be born. Treatment course of both groups lasted for 5 d. The distribution of muscle soreness were observed. The onset time and dura-tion of muscle soreness were also observed as well as pain relief and the occurrence of ADR in group A and B. RESULTS:Among 84 cases,the incidence of muscle soreness was 66.67%,among which mild pain accounted for 23.81%,moderate pain accounted for 13.10%,and severe pain accounted for 29.76%. Among 56 patients with muscle soreness,earliest muscle soreness occurred on the day of medication,and most of muscle soreness occurred on 1-3 days after medication,mainly manifesting as sore,activity limitation when severe,associated with fatigue. The pain relief rate of group A and B were 100%,but the incidence of adverse re-actions in group A was significantly lower than group B,with statistical significances(P<0.05).CONCLUSIONS:Diclofenac sodi-um is similar to paracetamol and tramadol hydrochloride in the treatment of PTX-induced muscle soreness,but it is better than paracetamol and tramadol hydrochloride in safety.关键词
双氯芬酸钠/氨酚曲马多/紫杉醇/肌肉酸痛/疗效/安全性Key words
Diclofenac sodium/Tramadol/Paclitaxel/Muscle soreness/Efficacy/Safety分类
医药卫生引用本文复制引用
胡丽丽,董超,王来成,尹弟,朱正秋,高超,黄广清,李晓..紫杉醇致肌肉酸痛发生情况分析及治疗[J].中国药房,2017,28(15):2063-2065,3.
