中国药房2017，Vol.28Issue(15)：2066-2068,3.DOI:10.6039/j.issn.1001-0408.2017.15.15
胺碘酮致肺毒性20例文献分析
Literature Analysis of 20 Cases of Amiodarone-induced Pulmonary Toxicity
杜美欣 1陈细兰 1刘晓琦1
作者信息
- 1. 广东省医学科学院/广东省人民医院药学部,广州 510080
- 折叠
摘要
Abstract
OBJECTIVE:To summarize general regularity and characteristics of amiodarone-induced pulmonary toxicity,and to provide reference for rational use of amiodarone and avoiding the occurrence of ADR. METHODS:Retrieved from CNKI,VIP and Wanfang database,individual case report literatures about amiodarone-induced pulmonary toxicity were collected during 1990-2016. The included cases were analyzed statistically. RESULTS:A total of 19 related literatures were collected,involving 20 cases of amiodarone-induced pulmonary toxicity. Among them,the patients older than 60 years old accounted for 75.0% with ratio of male to female 3:1. 75.0% patients had used medicine more than 1 month when pulmonary toxicity occurred. The dose of amiod-arone in 17 patients ranged 200-400 mg/d. Six patients died,accounting for 30.0%. CONCLUSIONS:Pulmonary toxicity induced by amiodarone may be related to patients'gender,age,dose and medication time. The mortality of it is in relative high level. Med-ical staff should pay attention to it,regularly monitor and process it timely.关键词
胺碘酮/肺毒性/文献分析Key words
Amiodarone/Pulmonary toxicity/Literature analysis分类
医药卫生引用本文复制引用
杜美欣,陈细兰,刘晓琦..胺碘酮致肺毒性20例文献分析[J].中国药房,2017,28(15):2066-2068,3.
