中国药房2017，Vol.28Issue(15)：2104-2107,4.DOI:10.6039/j.issn.1001-0408.2017.15.25
普乐士泰胶囊的质量标准研究
Study on Quality Standard of Prostatitis Capsules
摘要
Abstract
OBJECTIVE:To establish the quality standard for Prostatitis capsules. METHODS:TLC method was performed to qualitatively identify Pseudostellaria heterophylla,Acortw tatarinowii,Sargentodoxa cuneata,Rubia cordifolia and Vaccaria segeta-lis in the preparation. HPLC method was adopted to determine the content of leonurine in the preparation. The determination was performed on Agilent Eclipse XDB-C18 column with mobile phase consisted of methanol-0.025 mol/L potassium dihydrogen phos-phate(pH adjusted to 2.5)(24 : 76,V/V)with phosphoric acidat the flow rate of 1.0 mL/min. The detection wavelength was set at 277 nm,and column temperature was 30 ℃. The sample size was 10 μL. RESULTS:The TLC spots of P. heterophylla,A. tatari-nowii,S. cuneate,R. cordifolia,and V. segetalis were clear and well-separated without interference from negative control. The lin-ear range of leonurine were 4.05-81.00 μg/mL(r=0.9999). RSDs of precision,stability and reproducibility tests were all lower than 2.0%. The recovery was 98.47%-103.83%(RSD=2.04%,n=9). CONCLUSIONS:Established standard can be used for quali-ty control of Prostatitis capsules.关键词
普乐士泰胶囊/质量标准/薄层色谱法/益母草碱/高效液相色谱法Key words
Prostatitis capsules/Quality standard/TLC/Leonurine/HPLC分类
医药卫生引用本文复制引用
叶绿萍,宾彬,龚敏阳,唐春丽,马儒清..普乐士泰胶囊的质量标准研究[J].中国药房,2017,28(15):2104-2107,4.基金项目
广西壮族自治区卫生厅中医药科技专项课题(No.GZYZ1105) （No.GZYZ1105）
