RP-HPLC法测定洛索洛芬钠片的含量及有关物质OA北大核心CSTPCD
Determination of Contents and Related Substances in Loxoprofen Sodium Tablets by RP-HPLC
目的:改进测定洛索洛芬钠片中主成分含量及有关物质的方法.方法:采用反相高效液相色谱法.色谱柱为迪马Inspire C18,流动相为乙腈-0.01 mol/L磷酸二氢钾溶液(含0.2%三乙胺,磷酸调节pH至3.0±0.1)(62:38,V/V),流速为1.0 mL/min,柱温为40℃,检测波长为221 nm,进样量为20μL.结果:洛索洛芬钠峰与相邻杂质峰达到良好分离(分离度>1.5);洛索洛芬钠检测质量浓度线性范围为30.0~90.0μg…查看全部>>
OBJECTIVE:To improve the determination method for the contents of main components and related substances in Loxoprofen sodium tablets. METHODS:RP-HPLC method was adopted. The determination was performed on Inspire C18 column with mobile phase consisted of acetonitile-0.01 mol/L potassium dihydrogen phosphate(containing 0.2% triethylamine,phosphoric acid adjusted to 3.0±0.1,62 : 38,V/V)at the flow rate of 1.0 mL/min. The column temperature was 40 ℃,and the de…查看全部>>
袁浩宇;王鹏;易红;俞瑜
核工业四一六医院,成都 610051核工业四一六医院,成都 610051核工业四一六医院,成都 610051核工业四一六医院,成都 610051
医药卫生
反相高效液相色谱法洛索洛芬钠片含量有关物质
RP-HPLCLoxoprofen sodium tabletsContentRelated substances
《中国药房》 2017 (15)
2127-2130,4
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