中国药理学通报2017，Vol.33Issue(5)：607-611,5.DOI:10.3969/j.issn.1001-1978.2017.05.004
狂犬病毒糖蛋白中多肽片段作为脑靶向药物载体的研究进展
Advances of polypeptide fragment of rabiesvirus glycoprotein as a brain-targeting carrier
摘要
Abstract
Polypeptide fragment of rabies virus glycoprotein(RVG)has become one of the most popular polypeptides in drug delivery field,because of its advantages of neurotropiam,penetration of blood-brain barrier and biosafety.Polypeptide fragment of RVG can directly deliver proteins and nucleic acids into brain.Additionally,when polypeptide fragment of RVG couples with drug-loading polymers,nanoparticles or liposomes,it can mediate the latters into brain.The application of the RVG polypeptide fragment provides a safe and effective approach for the treatment of brain diseases with biomolecules,such as chemicals,proteins.plasmids,siRNA,miRNA.关键词
RVG肽/血脑屏障/脑靶向/多聚物/纳米载体/蛋白质/核酸Key words
RVG peptide/blood-brain barrier/brain targeting/polymer/nanoparticle/protein/nucleic acid分类
医药卫生引用本文复制引用
陈利刚,吴静,罗朋,付爱玲..狂犬病毒糖蛋白中多肽片段作为脑靶向药物载体的研究进展[J].中国药理学通报,2017,33(5):607-611,5.基金项目
国家自然科学基金资助项目(No81273416) （No81273416）
教育部回国人员启动基金[教外司留(2012)940号] （2012）
新世纪优秀人才支持计划 （）
