中国药理学通报2017，Vol.33Issue(5)：681-684,4.DOI:10.3969/j.issn.1001-1978.2017.05.018
5-羟色胺转运体基因多态性与慢性阻塞性肺疾病相关性研究
Relevance of 5-hydroxytryptamine transporter genepolymorphism and chronic obstructive pulmonary disease
摘要
Abstract
Aim To investigate the relevance of 5-hydroxytryptamine transporter(SERT)gene polymorphism and chronic obstructive pulmonary disease(COPD).Methods A total of 51 COPD patients and 49 healthy controls were collected.SERT gene polymorphism and mRNA expression in COPD and control groups were assayed by PCR and real-time PCR,respectively.Lung function was evaluated by a forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC)and FEV1/FVC.Results Two allele gene 484 bp and 528 bp were detected.It consisted of three genotypes L/L(528/528),L/S(528/484)and S/S(484/484),and SS genotype was prevalent in control and COPD group;SERT mRNA expression in COPD group was higher than that in the control;L allele in COPD with PAH patients was higher than the control.The age at diagnosis of COPD in LS genotype patients was earlier compared with that in SS genotype patients.Conclusion SERT gene polymorphism is relevant to hereditary susceptibility of COPD,which may play an important role in the development of COPD,especially promoting PAH in advanced stage of COPD.关键词
5-羟色胺/5-羟色胺转运体/基因多态性/慢性阻塞性肺疾病/肺动脉高压/遗传易感性Key words
5-hydroxytryptamine/5-hydroxytryptamine transporter/gene polymorphism/chronic obstructive pulmonary disease/pulmonary arterial hypertension/hereditary susceptibility分类
医药卫生引用本文复制引用
李雪芹,李运景,赵伟国,缪炯燏,王怀良..5-羟色胺转运体基因多态性与慢性阻塞性肺疾病相关性研究[J].中国药理学通报,2017,33(5):681-684,4.基金项目
国家自然科学基金资助项目(No81273511) （No81273511）
广东省医学科研基金资助项目(NoA2010744) （NoA2010744）
