中山大学学报（医学科学版）2017，Vol.38Issue(3)：327-331,5.
艾塞那肽抑制子宫内膜癌Ishikawa细胞株裸鼠移植瘤的血管生成
Exenatide Weaks Tumor Angiogenesis within Endometrial Cancer Ishikawa Xenografts in Nude Mice
摘要
Abstract
[Objective] To investigate the role of exenatide on angiogenesis in endometrial cancer Ishikawa xenografts in nude mice.[Method] We used the subcutaneous human endometrial cancer cell Ishikawa xenografts in nude mice model,and divided them into control group and exenatide-treated group.The harvested tumors were preserved for immunohistochemistry staining and western blot analysis.[Results] The micro-vessel density (CD31 positive) in exenatide-treated group was (13.2 ± 1.4)/400 power field,less than that in control group [(25.9 ± 5.8)/400 power field] (P ＜ 0.01).The expression level of VEGF was significantly lower in exenatide-treated group than that in control group (P ＜ 0.05).The mean density of tumor associated macrophages (F4/80 positive) is (31.4 ± 3.4)％ in exenatide-treated group and (72.1 ± 4.2)％ in control group with significant difference (P ＜ 0.01).[Conclusion] Exenatide weaks tumor angiogenesis within endometrial cancer Ishikawa xenografts in nude mice.关键词
艾塞那肽/子宫内膜癌/Ishikawa/血管生成Key words
exenatide/endometrial cancer/Ishikawa/angiogenesis分类
医药卫生引用本文复制引用
张宇,成娟,徐芬..艾塞那肽抑制子宫内膜癌Ishikawa细胞株裸鼠移植瘤的血管生成[J].中山大学学报（医学科学版）,2017,38(3):327-331,5.基金项目
国家自然科学青年基金(81300705) （81300705）
