中山大学学报（医学科学版）2017，Vol.38Issue(3)：379-385,7.
上皮性卵巢癌中Gal-3和Bcl-2的表达及临床意义
Expression of Galectin-3 and Bcl-2 in Epithelial Ovarian Cancer and Their Clinical Significance
摘要
Abstract
[Objective] Examine the expression of Galectin-3 (Gal-3),B cell lymphoma-2 protein (Bcl-2) in epithelial ovarian cancer tissues with regard to clinicopathological and survival variables,testing whether they can serve as prognostic markers and provide evidence for further research.[Methods] 98 EOC tissues and 10 normal ovarian tissues were collected,as well as their clinical documents.The expression of Gal-3 and Bcl-2 was tested via immunohistochemical staining analysis.Then the correlation between these two proteins and the clinicopathological and survival variables of these patients were evaluated.[Results] Of the 98 EOC,Gal-3 and Bcl-2 were all cytoplasmic staining.Gal-3 was observed in a majority of the EOC tumor cell proper (75/98,76.5％) but not in normal ovarian tissues.Bcl-2 was observed in a majority of the EOC tumor cell proper (50/98,51.0％) but not in normal ovarian tissue.Spearman bivariate correlation test show that there was no correlation between the expression Gal-3 and Bcl-2 (P =0.867).Gal-3 expression in EOC was associated with histology and platinum sensitivity (P =0.043,P =0.038),while Bcl-2 was associated with FIGO stage (P =0.029).Cox univariate analysis revealed that Gal-3,Bcl-2 expression,platinum sensitivity,stage were associated with overall survival (P =0.008,P =0.021,P ＜ 0.001,P ＜ 0.001).Further multivariate analysis showed that only Gal-3 expression,platinum sensitivity,stage affected the survival of these patients (P =0.014,P =0.021,P ＜ 0.001).[Conclusions]The expression of Gal-3 and Bcl-2 in EOC was significantly higher than that in normal ovarian tissue,supposed that they may involve in the development and progression of EOC.Gal-3 expression was associated with histology,platinum sensitivity and survival,it may be an independent predictive factor for EOC prognosis.There was no correlation between the expression Gal-3 and Bcl-2 in EOC,the functional mechanism between these two protein need further research.关键词
上皮性卵巢癌/半乳糖凝集素-3/B淋巴细胞瘤/白血病蛋白-2/临床意义/预后Key words
epithelial ovarian cancer/galectin-3/bcl-2/clinical significance/prognosis分类
医药卫生引用本文复制引用
王东雁,林仲秋,刘昀昀,黄纯娴,卢淮武..上皮性卵巢癌中Gal-3和Bcl-2的表达及临床意义[J].中山大学学报（医学科学版）,2017,38(3):379-385,7.基金项目
国家青年科学基金(81602290) （81602290）
广州市科技计划项目(201601020102) （201601020102）
