中国中西医结合杂志2017，Vol.37Issue(5)：534-538,5.DOI:10.7661/j.cjim.20170315.035
紫龙金片维持治疗晚期非小细胞肺癌患者的疗效观察
Maintenance Therapy of Zilongjin Tablet for Advanced Non-small-cell Lung Cancer Patients: Efficacy Observation
摘要
Abstract
Objective To observe the clinical efficacy and quality of life (QOL) of Zilongjin Tablet (ZT) as maintenance therapy for patients with locally advanced non-small-cell lung cancer (NSCLC).Methods Sixty-six patients with relieved or stable locally advanced NSCLC were randomly assigned to the treatment group and the control group,33 in each group.Patients in the treatment group took ZT (0.65 g/tablet),4 tablets each time,thrice per day.Patients in the control group took placebos,4 tablets each time,thrice per day.Progression-free survival (PFS) was statistically analyzed,1-year survival rate and 2-year survival rate were calculated,and changes of QOL were observed.Results Four cases dropped out in the process.Efficacy could be assessed in 62 cases,30 in the treatment group and 32 in the control group.Progression free survival (PFS) was 9.20 months in the treatment group and 6.23 months in the control group,with statistical difference (P ＜0.05).One year survival rate was 73.0％ in the treatment group,better than that of the control group (51.7％),with statistical difference between two groups (P ＜ 0.05).Two years survival rate was 52.0％ and 48.6％ respectively in the two groups,with no statistical difference (P ＞0.05).Compared with the control group,scores of physical,role,social,global QOL decreased,and disease-related symptoms such as fatigue,dyspnea,cough were improved in treatment group (P ＜0.05).In the treatment group symptoms such as fatigue,less of strength,shortage of qi,laziness for talking,dizziness,dim of sight,anorexia,cough,spontaneous sweating were all improved (P ＜0.05).Adverse reactions could be accepted by all patients in the two groups.Conclusions Maintenance treatment of ZT was safe and feasible for locally advanced NSCLC patients.It could prolong PFS and one-year survival rate,improve symptoms of Chinese medicine,and elevate their QOL.关键词
紫龙金片/局部晚期非小细胞肺癌/维持治疗/无进展生存时间/生活质量Key words
Zilongjin Tablet/locally advanced non-small-cell lung cancer/maintenance treatment/progression-free survival/quality of life引用本文复制引用
陈遐林,孙彩萍,王建芳..紫龙金片维持治疗晚期非小细胞肺癌患者的疗效观察[J].中国中西医结合杂志,2017,37(5):534-538,5.基金项目
浙江省中医药科技计划资助项目(No.2012ZB160) （No.2012ZB160）
