长春中医药大学学报2017，Vol.33Issue(3)：442-445,4.DOI:10.13463/j.cnki.cczyy.2017.03.032
补阳还五汤加减联合依帕司他治疗2型糖尿病周围神经病变
Buyang Huanwu decoction combined with Epalrestat in the treatment of type 2 diabetic peripheral neuropathy
摘要
Abstract
Objective To investigate the clinical effect of Buyang Huanwu decoction combined with Epalrestat in the treatment of type 2 diabetic peripheral neuropathy. Methods 72 cases with type 2 diabetic peripheral neuropathy from diabetes department of our hospital were selected and randomly divided into 2 groups, 36 cases each. The control group received epalrestat treatment, and the study group received more with Buyang Huanwu decoction, 2 groups were treated for 4 weeks. Clinical indexes, blood serum index , and adverse reaction condition were compared after the treatment. Results Compared with the control group, the motor nerve and sensory nerve conduction velocity in the study group were higher, scores of pain, burning sensation, paresthesia and numbness were lower, levels of serum CRP, 8-iso-PGF2α and TNF-α and IL-6 were lower, levels of T-AOC and MDA were lower, and levels of SOD were higher (P<0.05), there were no patients were followed off phenomenon, there were no differences in adverse rate comparison (P>0.05). Conclusion Buyang Huanwu decoction combined with epalrestat in the treatment of type 2 diabetic peripheral neuropathy was effective, and the mechanism may reduce the inflammatory factor, improve the ability of antioxidation.关键词
补阳还五汤/依帕司他/2型糖尿病周围神经病变Key words
Buyang Huanwu decoction/epalrestat/type 2 diabetic peripheral neuropathy分类
医药卫生引用本文复制引用
黄寅銮,曾纪斌,许希雪,林嘉妮,龚丽,曾超..补阳还五汤加减联合依帕司他治疗2型糖尿病周围神经病变[J].长春中医药大学学报,2017,33(3):442-445,4.基金项目
广东省医学科研基金资助项目(A2012258). （A2012258）
