长春中医药大学学报2017，Vol.33Issue(3)：466-468,3.DOI:10.13463/j.cnki.cczyy.2017.03.041
知柏地黄丸联合基础治疗对慢性牙周炎患者血清及龈沟液相关炎性因子的影响
Effect of Zhibai Dihuang pills combined with basic treatment on the serum and GCF related inflammatory cytokines in patients with chronic periodontitis
摘要
Abstract
Objective To explore the effect of Zhibai Dihuang pills combined with basic treatment on the serum and GCF related inflammatory cytokines in patients with chronic periodontitis. Methods A total of 120 patients with CP who were admitted in our hospital from June 2015 to November 2016 were included in the study and divided into the observation group and the control group with 60 cases in each group according to different treatment protocols. The patients in the control group were given periodontal basic treatments and anti-infection. On this basis, the patients in the observation group were given Zhibai Dihuang pills, 6 g/time, 2 times/d. After 4-week treatment, the efficacy was evaluated. The morning fasting peripheral venous blood and GCF specimen before treatment, 2 and 4 weeks after treatment in the two groups were collected. ELISA was used to detect the serum and GCF TNF-α and IL-1β. Six index teeth were served as the detected teeth. PLI, PD, SBI, and AL before treatment, 2 and 4 weeks after treatment in the two groups were recorded. Results The serum and GCF TNF-α and IL-1β levels 2 and 4 weeks after treatment in the observation group were significantly lower than those in the control group (P<0.05). SBI, PD, and AL 2 and 4 weeks after treatment in the observation group were significantly lower than those in the control group (P<0.05). The total effective rate in the observation group (93.33%) was significantly higher than that in the control group (78.33%) (P<0.05). Conclusions Zhibai Dihuang pills in combined with basic treatment in the treatment of CP can significantly reduce the inflammatory reaction, improve the periodontitis related clinical indicators, and enhance the therapeutic effect; therefore, it deserves to be widely recommended in the clinic.关键词
知柏地黄丸/慢性牙周炎/龈沟液/炎性因子Key words
Zhibai Dihuang pills/chronic periodontitis/GCF/inflammatory cytokine分类
医药卫生引用本文复制引用
赵雁焕,杨春霞,曹伟..知柏地黄丸联合基础治疗对慢性牙周炎患者血清及龈沟液相关炎性因子的影响[J].长春中医药大学学报,2017,33(3):466-468,3.基金项目
河北省医学科技进步获奖项目(151162-5-4). （151162-5-4）
