王模奎 1董文斌 2黄薇 1苏华英 1杨介梅 1王琴 1吕勇彬 1卢婷1
作者信息
- 1. 宜宾市第一人民医院,四川宜宾644000
- 2. 西南医科大学附属医院,四川泸州646000
- 折叠
摘要
Abstract
Objective:To evaluate the efficacy of early salvaged using of bovine pulmonary surfactant (PS) on preterm infants with severe respiratory distress syndrome (RDS),to offer the information for clinical treatment.Methods:Retrospected analysed the children's data of 86 preterm infants,who had been admitted to NCIU and with bovine PS salvaged using because of severe RDS,from January 2012 to May 2016.Data were collected,such as general information,usage of PS,duration of hospital stay,the time of oxygen therapy,mechanical ventilation,and nasal continuous positive airway pressure (nCPAP),oxygenation index(OI)before and after PS administration,survival rate of 28 days after birth,complication.All the children were divided into early group (＜2 h) and delayed group (≥ 2 h) according to the age when the onset of the first dose of PS administration,respectively.Results:The general information,OI before PS administration,duration of hospital stay and the time of nCPAP,the rate of nCPAP and complications such as pulmonary hemorrhage had no significant differences between the two groups (all P＞0.05).The OI were continue decreased in the two groups,but only OI in 12 h and 72 h were significantly lower than before.There were 74 (86.0％) survivors in all the 86 cases,and the survival rate was 95.0％ in early group,significantly higher than that of 78.3％ in delayed group (x2 =4.99,P＜0.05).In early group and delayed group,the rates of bronchopulmonary dysplasia (BPD) were 2.5％ and 19.6％,duration of mechanical ventilation were 120.0 (96.0,143.0) h and 133.0 (72.0,148.0) h,the time of oxygen therapy were 8.0 (7.0,12.0) d and 12.0 (8.0,15.0) d,the rate of PS reuse were 57.5％ and 80.4％,and the interval of PS reuse were 20.0 (18.0,22.0) h and 19.0 (18.0,20.0) h,respectively (all P＜0.05).Conclusion:Early salvaged using of bovine PS,not only significantly decrease the mortality and rate of BPD,the duration of mechanical ventilation and oxygen therapy,but also delay the interval and reduce the opportunity of repeated PS in preterm infants with severe RDS.关键词
早期/早产儿/呼吸窘迫综合征/牛肺表面活性物质Key words
early/preterm infant/respiratory distress syndrome/bovine pulmonary surfactant分类
医药卫生
