摘要
Abstract
Objective:To investigate the clinical efficacy and safety of montelukast sodium combined with budesonide in the treatment of children with bronchiolitis,and its impact on children with inflammatory factor.Methods:One hundred and six cases of children with bronchiolitis in our hospital from February 2014 to February 2016 were randomly divided into the control group and the observation group,53 cases in each group.Two groups were given conventional treatment of expectorant,antitussive,antiasthmatic and antiinfection and anti-virus etc.,the control group based on those was given budesonide,while the observation group on the basis of the control group was given montelukast sodium,the course of treatment in the two groups for 7 days.Observed and recorded the clinical efficacy,adverse reactions after treatment of one course of treatment in two groups,meanwhile,compared of the duration time of coughing,lung rale,wheeze,and hospitalization,and the improvement of the levels of the serum eosinophils cationic protein (ECP),interleukin-4 (IL-4),interleukin-8 (IL-8),and tumor necrosis factor-α (TNF-α).Results:The total efficacy of the observation group was 92.5％,which was significantly higher than that of 75.5％ in the control group,the difference was statistically significant (P＜0.05).The duration time of coughing,lung rale,wheeze,and hospitalization in observation group was significantly shorter than those in control group,the differences were statistically significant (P＜0.05).At the same time,after treatment,the levels of serum ECP,IL-4,IL-8 and TNF-α in the two groups were significantly improved,and the improvement in observation group was significantly better than the control group,the differences were statistically significant (P＜0.05).Among the treatment,the two groups had no obvious adverse reactions.Conclusion:Montelukast sodium combined with budesonide in the treatment of children with bronchiolitis has significant effect,and can significantly improve the levels of serum ECP,IL-4,IL-8,and TNF-α,and has a high safety,it is worth of clinical popularizing and application.关键词
孟鲁司特钠/布地奈德/儿童/毛细支气管炎Key words
montelukast sodium/budesonide/children/bronchiolitis分类
医药卫生
