临床与病理杂志2017，Vol.37Issue(4)：661-666,6.DOI:10.3978/j.issn.2095-6959.2017.04.002
276例手术切除肺腺癌亚型与EGFR/ALK基因状态
EGFR/ALK gene status of 276 cases of surgically resected lung adenocarcinomas
摘要
Abstract
Objective:To investigate the mutations of EGFR gene and ALK fusion gene in surgically resected lung adenocarcinomas.Methods:ARMS method was used to detect the tissues in 276 patients of surgically resected lung adenocarcinomas with paraffin tissue EGFR gene mutation and ALK fusion gene.Results:The total mutation rate in 276 patients of surgically resected lung adenocarcinomas was 54.71％ (151/276).EGFR gene mutation rate were found in 19del (28.99％,80/276),L858R (23.19％,64/276),20-ins (0.72％,2/276),L861Q(0.72％,2/276),G719X (1.09％,3/276),S768I (0.36％,1/276) and T790M (0.72％,2/276) in surgically resected lung adenocarcinomas,including one case of G719X+S768I,19del+T790M,L858R+T790M,respectively.The total fusion positive rate in 207 patients of surgically resected lung adenocarcinomas was 5.80％ (12/207).There were statistically significant (P＜0.001,P＜0.001,P=0.023,P＜0.001 and P=0.030) in each subtype of lung adenocarcinoma ofEGFR gene mutation,including lepidic predominant adenocarcinoma,acinar predominant adenocarcinoma,papillary predominant adenocarcinoma,solid predominant adenocarcinoma and invasive mucous adenocarcinoma,and there were not statistically significant (P＞0.05) among other types.There were not statistically significant (P＞0.05) among each types of lung adenocarcinoma of ALK fusion gene.Conclusion:Histologic subtyping was found to be associated with EGFR mutations.The EGFR mutation frequency of lepidic predominant,acinar predominant and papillary predominant subtypes was found to be more pronounced than that of other subtypes.关键词
肺腺癌/手术/EGFR基因/ALK基因/突变率Key words
lung adenocarcinoma/surgery/EGFR gene/ALK gene/mutation rate引用本文复制引用
庄武,林贤东,许春伟,陈刚,钟礼花,陈芳芳,陈燕坪,黄韵坚,黄章洲,卢建平,王晓江,师怡..276例手术切除肺腺癌亚型与EGFR/ALK基因状态[J].临床与病理杂志,2017,37(4):661-666,6.基金项目
国家临床重点专科建设项目(2013) （2013）
福建省科技厅引导性项目(2015Y0011,2016Y0019).This work was supported by National Clinical Key Specialty Construction Program (2013),Leading Project Foundation of Science Department of Fujian Province (2015Y0011,2016Y0019),China. （2015Y0011,2016Y0019）
