临床与病理杂志2017，Vol.37Issue(4)：667-672,6.DOI:10.3978/j.issn.2095-6959.2017.04.003
PRSS3-mRNA与长链非编码RNA-PRSS3P2在甲状腺乳头状癌组织中的表达及其临床意义
Expression and clinical significance of PRSS3-mRNA and LncRNA-PRSS3P2 in papillary thyroid carcinoma
摘要
Abstract
Objective:To detect the expressions of PRSS3-mRNA and lncRNA-PRSS3P2 in PTCs and their corresponding normal thyroid tissues,and to explore the clinicopathologic significance of PRSS3 and PRSS3P2 in PTC.Methods:A total of 55 fresh tissues of PTC plus with their paired normal thyroid tissues resected between July 1 and October 31,2016 were collected.The expressions of PRSS3-mRNA and lncRNA-PRSS3P2 were detected by real-time quantitative PCR.The relationship between expressions of PRSS3/PRSS3P2 and the clinicopathologic features were carefully analyzed.Results:The expression levels of PRSS3 and PRSS3P2 in PTC tissues were obviously higher than their non-tumor counterparts (P＜0.05).PRSS3P2 was correlated with the age of patients (P＜0.05);however,PRSS3 is not associated with the clinicopathologic features of PTC.Conclusion:The expressions of PRSS3-mRNA and lncRNA-PRSS3P2 were increased in PTC.The present findings indicate that PRSS3 and PRSS3P2 may participate the development of PTC.PRSS3-mRNA and lncRNA-PRSS3P2 can be served as two potential diagnostic markers for PTC.关键词
甲状腺乳头状癌/丝氨酸蛋白酶3/长链非编码RNAKey words
papillary thyroid carcinoma/protease serine 3/long non-coding RNA引用本文复制引用
何冰,王继纲,李玉军..PRSS3-mRNA与长链非编码RNA-PRSS3P2在甲状腺乳头状癌组织中的表达及其临床意义[J].临床与病理杂志,2017,37(4):667-672,6.基金项目
国家自然科学基金(81502272).This work was supported by the National Natural Science Foundation of China (81502272). （81502272）
