临床与病理杂志2017，Vol.37Issue(4)：729-734,6.DOI:10.3978/j.issn.2095-6959.2017.04.014
埃克替尼对非小细胞肺癌EGFR 18外显子突变的临床疗效
Clinical efficacy of icotinib in patients with advanced non-small cell lung cancer harboring EGFR exon 18 mutations
摘要
Abstract
Objective:To investigate the efficacy oficotinib in patients with non-small cell lung cancer (NSCLC) that carrying G719X/E709X/G724S in EGFR exon 18.Methods:We retrospectively analysed 24 cases of EGFR 18 exon rare mutation NSCLC patients until the progress of the disease or the emergence of the side effects and clinical efficacy was observed after months followed-up.Results:Twenty-four patients with G719X/E709X/G724S mutations were enrolled.Mutations including G719X,E709X and G724S mutations were observed in 19,3 and 2 patients,respectively.In total,the median progression-free survival (PFS) were 3.1 months,respectively.Patients with G724S mutation manifested the longest median PFS (3.5 months),followed by those with E709X (3.1 months) and G719X (2.8 months).Patients with complex mutations showed a better PFS than those with single mutations (G719X mutations 3.3 months vs.2.6 months,P=0.029;E709X 7.2 months vs.2.7 months,P=0.225).Conclusion:Icotinib is less effective in patients with exon 18 uncommon mutations than in those with common mutations.Patients with complex mutations benefited more from icotinib than those with single mutations.关键词
非小细胞肺癌/埃克替尼/18外显子Key words
non-small cell lung cancer/icotinib/exon 18引用本文复制引用
黄韵坚,林贤东,许春伟,陈刚,陈燕坪,庄武,黄章洲,朱有才,杜开齐,方美玉,王晓江,师怡..埃克替尼对非小细胞肺癌EGFR 18外显子突变的临床疗效[J].临床与病理杂志,2017,37(4):729-734,6.基金项目
国家临床重点专科建设项目(2013) （2013）
福建省科技厅引导性项目(2016Y0019) （2016Y0019）
福建省科技厅引导性项目(2015Y0011) （2015Y0011）
浙江省卫生科研计划基金(2013KYB051) （2013KYB051）
浙江省中医药局科研基金(2013ZQ005) （2013ZQ005）
浙江省科技厅公益类科研计划(2015C33194).This work was supported by National Clinical Key Specialty Construction Program (2013) （2015C33194）
Leading Project Foundation of Science Department of Fujian Province (2016Y0019) （2016Y0019）
Leading Project Foundation of Science Department of Fujian Province (2015Y0011) （2015Y0011）
Medical Scientific Research Foundation of Zhejiang Province (2013KYB051) （2013KYB051）
Zhejiang Administration of Traditional Chinese Medicine Foundation (2013ZQ005) （2013ZQ005）
The Science and Technology Planning Project of Zhejiang Province (2015C33194),China. （2015C33194）
