临床与病理杂志2017，Vol.37Issue(4)：784-790,7.DOI:10.3978/j.issn.2095-6959.2017.04.023
75例原发性胃肠道淋巴瘤的临床病理分析
Clinicopathological analysis of 75 cases of primary gastrointestinal lymphoma
摘要
Abstract
Objective:To analyze the clinical and pathological characteristics of patients with primary gastrointestinal lymphoma (PGIL).Methods:Clinical and pathological information of 75 patients with PGIL admitted to Renmin Hospital of Wuhan University from January 2011 to January 2017 was investigated retrospectively.Results:Of 75 patients with PGIL,45 were male and 30 were female,with an average age of 56.96±14.51 years old.Forty-three patients (57.33％) were presented with abdominal pain,51 patients (68.00％) were detected with high level of CEA and 17 patients (32.69％) patients were detected with OB(+).The positive rate of endoscopy was 93.75％ and the positive rate of digital rectal examination was 55.56％.There were 45 cases of diffuse large B-cell lymphoma (DLBCL),13 cases of mucosa-associated lymphoid tissue (MALT),6 cases of anaplastic large cell lymphoma (ALCL),4 cases of peripheral T-cell lymphoma (PTCL),and 7 cases of other pathological types.According to Ann Arbor criteria,there were 7 cases (9.33％) with stage IE,25 cases (33.33％) with stage ⅡE,11 cases (14.67％) with stage ⅢE and 32 cases (42.67％) with stage WE.41 patients underwent chemotherapy of CHOP regimen and 12 patients received R-CHOP regimen.Three patients accepted surgical treatmenL and 19 patients gave up treatment.Conclusion:PGIL is more likely to occur among middle-age and old male patients,and the most common clinical manifestation is abdominal pain.Confirmed diagnosis is made by biopsy under endoscopy and laparoscopic exploration.Tumor makers and OB of stool play a certain role in diagnosing PGIL and digital rectal examination is crucial for rectal lymphoma.PGL is more likely to occur on the early stage of this tumor,while PIL is more likely to occur on the advanced stage.Its most common pathological types are DLBCL and MALT.The therapy of DLBCL is CHOP/R-CHOP,and the treatment of MALT is eradication of HE Surgery is mainly applied to deal with the complications of PGIL.关键词
原发性胃肠道淋巴瘤/临床诊断/病理特征/分期Key words
primary gastrointestinal lymphoma/clinical diagnosis/pathological features/clinical stage引用本文复制引用
廖斐,詹娜,田山,尹清明,董卫国..75例原发性胃肠道淋巴瘤的临床病理分析[J].临床与病理杂志,2017,37(4):784-790,7.基金项目
国家自然科学基金(81372551).This work was supported by the National Natural Science Foundation of China (81372551). （81372551）
