临床与病理杂志2017，Vol.37Issue(4)：813-818,6.DOI:10.3978/j.issn.2095-6959.2017.04.028
磷脂酰肌醇3激酶/蛋白激酶B/雷帕霉素靶蛋白信号通路在肺部疾病中的研究进展
Research progress of phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin signal pathway in pulmonary diseases
摘要
Abstract
Phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR)signal pathway is an important intracellular signal pathway,playing pivotal role in cell growth,proliferation,differentiation,DNA synthesis.Pulmonary carcinoma,asthma,pulmonary artery hypertension,pulmonary fibrosis,chronic pulmonary obstructive disease (COPD) are common chronic respiratory diseases,and their patho-mechanisms involve cell proliferation and growth,which have intimate relationship with PI3K/Akt/mTOR.关键词
磷脂酰肌醇3激酶/蛋白激酶B/雷帕霉素靶蛋白信号通路/呼吸系统疾病/病理机制Key words
PI3K/Akt/mTOR signal pathway/pulmonary disease/pathogenesis引用本文复制引用
杨春兰..磷脂酰肌醇3激酶/蛋白激酶B/雷帕霉素靶蛋白信号通路在肺部疾病中的研究进展[J].临床与病理杂志,2017,37(4):813-818,6.基金项目
国家自然科学基金(81270118) （81270118）
湖南省研究生创新性课题(CX2016B496).This work was supported by the National Natural Science Foundation (81270118) and Innovative Subject of Graduate Students in Hunan Province (CX2016B496),China. （CX2016B496）
