临床与病理杂志2017，Vol.37Issue(4)：862-867,6.DOI:10.3978/j.issn.2095-6959.2017.04.036
二甲双胍对糖尿病肾病的保护作用及其抗氧化应激机制
Metformin protects diabetic nephropathy and its antioxidation mechanism
摘要
Abstract
Hyperglycemia can promote the generation of reactive oxygen species and result in oxidative stress in vivo.Oxidative stress plays an important role in the occurrence and development of diabetic nephropathy (DN).Besides the hypoglycemic effect,metformin,as the first-line drug for the treatment of diabetes,can prevent and delay the occurrence and progress of DN through some antioxidation mechanisms,including activation of the AMP activated protein kinase (AMPK),phosphorylated p38 mitogen-activated protein kinase (p-p38MAPK),stimulate the expression of NAD(P)H quinone oxidoreductase (NQO1),glutathione S-transferase-a (GSTa),and catalase (CAT),block advanced glycation end products (AGEs),reduce the expression of GADPH oxidase,improve the insulin resistance and so on.关键词
二甲双胍/糖尿病肾病/氧化应激Key words
metformin/diabetic nephropathy/oxidative stress引用本文复制引用
余丹..二甲双胍对糖尿病肾病的保护作用及其抗氧化应激机制[J].临床与病理杂志,2017,37(4):862-867,6.基金项目
安徽省自然科学基金(11040606M159).This work was supported by Natural Science Foundation of Anhui Province,China (11040606M159). （11040606M159）
